Recombinant Uroplakin 2 抗体 (AA 36-51)
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Quick Overview for Recombinant Uroplakin 2 抗体 (AA 36-51) (ABIN7858040)
抗原
See all Uroplakin 2 (UPK2) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 36-51
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原理
- Recombinant Uroplakin II (UPK2) (Urothelial Differentiation Marker) Antibody
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特异性
- Uroplakin II (UPII) is a 15- kDa protein comprising urothelial plaques, which fortify the urothelial barrier. It is a highly specific marker for tumors of urothelial origin, particularly urothelial carcinoma (UC). UPII messenger RNA has been detected in the tissue and blood of UC patients. Immunohistochemistry utilizing UPII antibodies, such as UPK2/13669R, exhibits high specificity and increased sensitivity for urothelial carcinoma compared to UPIII antibodies. UPII immunohistochemistry is valuable for differentiating urothelial carcinoma from other malignancies, including prostate adenocarcinoma or metastatic breast carcinoma. It has also shown promise for detecting micrometastases of bladder cancer. UPII expression is found in various UC subtypes like micro-papillary, plasmacytoid, and sarcomatoid variants.
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纯化方法
- 200ug/ml of Ab purified from Bioreactor Concentrate by Protein A.
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免疫原
- Recombinant fragment (around aa 36-51) of human Uroplakin 2 (UPK2) protein (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-Uroplakin 2 (UPK2) (AA 26-153) antibody
UPK2 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Uroplakin 2 (UPK2) antibodyUPK2 适用: 大鼠 WB 宿主: 兔 Polyclonal RB48641 unconjugated
anti-Uroplakin 2 (UPK2) (AA 85-155) antibodyUPK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Uroplakin 2 (UPK2)
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别名
- Uroplakin II
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背景
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UP2, UPII
Urinary bladder.
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分子量
- 195kDa
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基因ID
- 7379
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UniProt
- O00526
抗原
-
