Recombinant PVRL4 抗体 (Extracellular Domain)
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Quick Overview for Recombinant PVRL4 抗体 (Extracellular Domain) (ABIN7865529)
抗原
See all PVRL4 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 266-280, Extracellular Domain
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Expression System
- CHO Cells
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原理
- Recombinant Nectin 4 / Nectin Cell Adhesion Molecule 4 / PVRL4 Antibody
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特异性
- Homologous to the poliovirus receptor (PVR/CD155), the nectin immunoglobulin superfamily comprises four known isoforms (-1, -2, -3, and -4). The ectodomain of nectin family members comprises three Ig-like domains (V, C, C). Nectins localize at the adherens junctions (AJ) in epithelial and endothelial cells where they serve as adhesion molecules. Actin-based AJs play a role in mechanical adhesion, cellular morphogenesis and cellular differentiation. Nectin associates with the Actin cytoskeleton through its interaction with the Actin filament-binding protein afadin. Nectin 4 and afadin co-localize at cadherin-based adherens junctions in MDCKII epithelial cells. Nectin 4 and Nectin 3 share a common binding region in the V domain of Nectin 1 and thus compete for Nectin 1 binding. The Nectin 3/4 binding domain maps to the C-C'-C''-D b strands of the V domain of Nectin 1. Unlike other nectins, which are more widely expressed, Nectin 4 is mainly expressed in the placenta.
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纯化方法
- 200ug/ml of Ab produced in CHO cell mammalian-based expression system.
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免疫原
- Recombinant fragment (around aa266-280) of human NECTIN4 protein corresponding to the extracellular domain (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-Poliovirus Receptor-Related 4 (PVRL4) antibody
PVRL4 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 91-199) antibodyPVRL4 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 151-250) antibodyPVRL4 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (Internal Region) antibodyPVRL4 适用: 人, 小鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 84-96), (Extracellular) antibodyPVRL4 适用: 小鼠 WB, FACS 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 31-139) antibodyPVRL4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1D7 unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 1-510) antibodyPVRL4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 371-510) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Poliovirus Receptor-Related 4 (PVRL4) antibodyPVRL4 适用: 人 FACS 宿主: Human, 兔 Chimeric DMC438 unconjugated Fc fragment Recombinant Antibody
anti-Poliovirus Receptor-Related 4 (PVRL4) (AA 239-266) antibodyPVRL4 适用: 人 WB 宿主: 兔 Polyclonal RB37608 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody without azide - store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- PVRL4 (Poliovirus Receptor-Related 4 (PVRL4))
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别名
- Nectin 4
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背景
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Ig superfamily receptor LNIR family, Nectin 4, poliovirus receptor-related 4, Processed poliovirus receptor-related protein 4, PRR4, PVRL4
Human tonsil, placenta or breast. MCF-7 or T47D cells.
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分子量
- 66kDa
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基因ID
- 81607, 492490
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UniProt
- Q96NY8
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途径
- Cell-Cell Junction Organization
抗原
-
