Recombinant FOLR1 抗体 (Extracellular Domain)
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Quick Overview for Recombinant FOLR1 抗体 (Extracellular Domain) (ABIN7865461)
抗原
See all FOLR1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-200, Extracellular Domain
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Expression System
- CHO Cells
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原理
- Recombinant Folate Receptor Alpha (FRalpha) / FOLR1 Antibody
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特异性
- Folate receptor alpha (FR±) is a membrane-bound protein that facilitates high-affinity folate transport, essential for cell metabolism, DNA synthesis, and repair, particularly in rapidly dividing cancer cells with increased folate demands. This receptor, encoded by the FOLR1 gene, employs a potocytosis mechanism that leads to both membranous and cytoplasmic localization and is selectively overexpressed in certain epithelial malignancies while remaining highly restricted in normal tissues. FR± expression correlates with tumor stage and grade, suggesting a role in tumor progression by enhancing folate uptake or generating regulatory signals. Its regulation is influenced by extracellular folate levels, homocysteine accumulation, hormones, transcription factors, and genetic mutations. Members of the folate receptor family share highly conserved sequences in the open reading frames but differ in amino acids in the 5' untranslated regions and as a consequence can differ in function and tissue expression. Given the selective overexpression of FR± in tumors and its association with aggressive cancer phenotypes, FR± is a valuable marker for studying tumor biology and progression, particularly in epithelial cancers.
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纯化方法
- 200ug/ml of Ab produced in CHO cell mammalian-based expression system.
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免疫原
- Recombinant fragment (around aa1-200) of human FOLR1 protein corresponding to the extracellular domain (exact sequence is proprietary)
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亚型
- IgG, kappa
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anti-Folate Receptor 1 (Adult) (FOLR1) (AA 41-227) antibody
FOLR1 适用: 人 IHC, ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2G5C12 unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 25-234) antibodyFOLR1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) antibodyFOLR1 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 25-93) antibodyFOLR1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (Middle Region) antibodyFOLR1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 犬, 马, 兔 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 41-227) antibodyFOLR1 适用: 人 ELISA, FACS 宿主: 小鼠 Monoclonal 3G12B7 unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 33-68), (N-Term) antibodyFOLR1 适用: 人 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB28535 unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 1-257) antibodyFOLR1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 179-228) antibodyFOLR1 适用: 人, 小鼠, 大鼠, Hamster, 犬, 马, 兔, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Folate Receptor 1 (Adult) (FOLR1) (AA 25-234) antibodyFOLR1 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- FOLR1 (Folate Receptor 1 (Adult) (FOLR1))
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别名
- Folate Receptor Alpha
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背景
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DOM, PCWH, SOX10, SRY (sex determining region Y) box 10, SRY box containing gene 10, SRY related HMG box gene 10, Waardenburg syndrome type 2E(WS2E), WS4, Waardenburg syndrome type 4C (WS4C)
Human kidney, thymus, placenta or lung. Human Brain, Mouse Brain, Rat Brain or Guinea pig Brain
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分子量
- 29kDa
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基因ID
- 2348
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UniProt
- P15328
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途径
- Dicarboxylic Acid Transport
抗原
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