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Caldesmon 抗体 (C-Term)

This 兔 单克隆 antibody specifically detects Caldesmon in WB, IHC, IF, FACS, IHC (p) 和 ICC. It exhibits reactivity toward 人, 大鼠 和 小鼠.
产品编号 ABIN7849506
发货至: 中国
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Quick Overview for Caldesmon 抗体 (C-Term) (ABIN7849506)

抗原

See all Caldesmon (CALD1) 抗体
Caldesmon (CALD1) (Caldesmon 1 (CALD1))

适用

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人, 大鼠, 小鼠

宿主

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克隆类型

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单克隆

标记

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This Caldesmon antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
  • 抗原表位

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    C-Term

    原理

    Monoclonal Anti- Caldesmon antibody

    纯化方法

    Protein A affinity purified

    免疫原

    Asynthetic peptide within C-terminal human Caldesmon.

    亚型

    IgG
  • 应用备注

    Western Blot, WB(1:500-1:1, 000), Immunohistochemistry, IHC-P (1:20-1:100), Immunocytochemistry, ICC/IF (1:20-1:100), Flow Cytometry, Flow-Cyt (1:20-1:50),

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    1*PBS ( pH 7.4), 0.2 % BSA, 40 % Glycerol and 0.05 % Sodium Azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

    有效期

    12 months
  • 抗原

    Caldesmon (CALD1) (Caldesmon 1 (CALD1))

    别名

    Caldesmon

    背景

    Caldesmon is a protein that in humans is encoded by the CALD1 gene.Caldesmon (CDM) is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells. Domain mapping and physical studies suggest that CDM is an elongated molecule with an N-terminal myosin/calmodulin-binding domain and a C-terminal tropomyosin/actin/calmodulin-binding domain separated by a 40-nm-long central helix.1The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells.2The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction.

    途径

    Myometrial Relaxation and Contraction
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