Caldesmon 抗体 (C-Term)
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Quick Overview for Caldesmon 抗体 (C-Term) (ABIN7849506)
抗原
See all Caldesmon (CALD1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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原理
- Monoclonal Anti- Caldesmon antibody
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纯化方法
- Protein A affinity purified
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免疫原
- Asynthetic peptide within C-terminal human Caldesmon.
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亚型
- IgG
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应用备注
- Western Blot, WB(1:500-1:1, 000), Immunohistochemistry, IHC-P (1:20-1:100), Immunocytochemistry, ICC/IF (1:20-1:100), Flow Cytometry, Flow-Cyt (1:20-1:50),
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- 1*PBS ( pH 7.4), 0.2 % BSA, 40 % Glycerol and 0.05 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C after thawing (1 week). Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.
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有效期
- 12 months
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- Caldesmon (CALD1) (Caldesmon 1 (CALD1))
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别名
- Caldesmon
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背景
- Caldesmon is a protein that in humans is encoded by the CALD1 gene.Caldesmon (CDM) is a potential actomyosin regulatory protein found in smooth muscle and nonmuscle cells. Domain mapping and physical studies suggest that CDM is an elongated molecule with an N-terminal myosin/calmodulin-binding domain and a C-terminal tropomyosin/actin/calmodulin-binding domain separated by a 40-nm-long central helix.1The high molecular weight caldesmon (h-CaD) is predominantly expressed in smooth muscles, whereas the low molecular weight caldesmon (l-CaD) is widely distributed in nonmuscle tissues and cells.2The conserved domain of this protein possesses the binding activities to Ca++-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca++-dependent inhibition of smooth muscle contraction.
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途径
- Myometrial Relaxation and Contraction
抗原
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