Recombinant SET7 抗体
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北京 101111
Quick Overview for Recombinant SET7 抗体 (ABIN7828560)
抗原
See all SET7 (SETD8P1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant SET7 Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-SET Domain Containing 8 Pseudogene 1 (SETD8P1) (AA 159-189) antibody
SETD8P1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SET Domain Containing 8 Pseudogene 1 (SETD8P1) (AA 289-317), (C-Term) antibodySETD8P1 适用: 人 WB 宿主: 兔 Polyclonal RB5744 unconjugated
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应用备注
- WB 1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- SET7 (SETD8P1) (SET Domain Containing 8 Pseudogene 1 (SETD8P1))
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别名
- SET7
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背景
- KMT,SETD,KIAA,SET,SETD7,KMT7,SET7,SET7/9,SET9,KIAA1717,SET7/SET9 is a member of the SET domain-containing family, and can specifically methylate Lys4 on histone H3. Like most other lysine directed histone methyltransferases, it contains a conserved catalytic SET domain originally identified in the Drosophila Su(var)3-9, Enhancer of zeste and Trithorax proteins. Histone methylation is a major determinant for the formation of active and inactive regions of the genome and is crucial for the proper programming of the genome during development. Methylation of histone H3 Lys4 enhances transcriptional activation by coordinating the recruitment of BPTF, a component of the NURF chromatin remodeling complex, and WDR5, a component of multiple histone methyltransferase complexes. In addition, methylation of lysine 4 blocks transcriptional repression by inhibiting the binding of the NURD histone deacetylation complex to the amino-terminal tail of histone H3 and interfering with SUV39H1 mediated methylation of histone H3 Lys9. SET7/SET9 is highly active on free histone H3, but only very weakly methylates H3 within nucleosomes. Besides histones, SET7/SET9 also methylates Lys189 of the TAF10, a member of the TFIID transcription factor complex, and Lys372 of the p53 tumor suppressor protein. Methylation of TAF10 stimulates transcription in a promoter-specific manner by increasing the affinity of TAF10 for RNA polymerase II, which may potentiate pre-initiation complex formation. Methylation of p53 at Lys372 increases protein stability and leads to upregulation of target genes such as p21. Thus the loss of SET7/SET9 may represent another mechanism for the inactivation of p53 in human cancers. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 41 kDa
Observed MW: 47 kDa The actual band is not consistent with the expectation.
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UniProt
- Q8WTS6
抗原
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