Recombinant RNF40 抗体
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北京 101111
Quick Overview for Recombinant RNF40 抗体 (ABIN7828533)
抗原
See all RNF40 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant RNF40 Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (AA 102-200) antibody
RNF40 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C1 unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) antibodyRNF40 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) antibodyRNF40 适用: 人 WB, IHC 宿主: 兔 Monoclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (AA 1-300) antibodyRNF40 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (AA 801-850) antibodyRNF40 适用: 人, 小鼠, 大鼠, 犬, 马, 猴, Cow, 豚鼠, 兔, Hamster WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (C-Term) antibodyRNF40 适用: 人, 小鼠, 大鼠, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (C-Term) antibodyRNF40 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (AA 471-724) antibodyRNF40 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) (AA 102-200) antibodyRNF40 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40) antibodyRNF40 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- RNF40 (Ring Finger Protein 40, E3 Ubiquitin Protein Ligase (RNF40))
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别名
- RNF40
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背景
- RBP,RNF,KIAA,RNF40,BRE1B,RBP95,STARING,KIAA0661,In mammalian cells, the significance of histone H2B ubiquitination in chromatin epigenetics came from the identification of the budding yeast protein Bre1. Together with the ubiquitin-conjugating enzyme Rad6, Bre1 serves as the E3 ligase in the monoubiquitination of the yeast histone H2B within transcribed regions of chromatin. Subsequently, the mammalian orthologs of yeast Bre1, RNF20 and RNF40, were identified. These two proteins form a tight heterodimer that acts as the major E3 ligase responsible for histone H2B monoubiquitination at Lys120 in mammalian cells, a modification linked to RNA Pol II-dependent transcription elongation in undamaged cells. Researchers have shown that DNA double-strand breaks (DSBs) are also capable of inducing monoubiquitination of H2B. This process depends upon the recruitment to DSB sites, as well as ATM-dependent phosphorylation of the RNF20-RNF40 heterodimer, thus highlighting a role for this E3 ligase in DSB repair pathways. Indeed, investigators have shown that loss of RNF20-RNF40 function promotes replication stress and chromosomal instability, which may constitute an early step in malignant transformation that precedes cell invasion. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 114 kDa
Observed MW: 140 kDa The actual band is not consistent with the expectation.
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UniProt
- O75150
抗原
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