Recombinant PKC mu 抗体
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北京 101111
Quick Overview for Recombinant PKC mu 抗体 (ABIN7828496)
抗原
See all PKC mu (PRKD1) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant PKC mu Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-Protein Kinase D1 (PRKD1) antibody
PRKD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (pTyr463) antibodyPRKD1 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) antibodyPRKD1 适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB4590 unconjugated Recombinant Antibody
anti-Protein Kinase D1 (PRKD1) (pSer910) antibodyPRKD1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 383-395) antibodyVerified PRKD1 适用: 人 WB, ELISA, IP 宿主: 山羊 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 233-246) antibodyVerified PRKD1 适用: 人 WB, ELISA, IHC, IP 宿主: 山羊 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 314-404) antibodyPRKD1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 1-912) antibodyPRKD1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 361-389), (N-Term) antibodyPRKD1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1037 unconjugated
anti-Protein Kinase D1 (PRKD1) (AA 171-220) antibodyPRKD1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:1000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- PKC mu (PRKD1) (Protein Kinase D1 (PRKD1))
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别名
- PKC mu
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背景
- PRKD,CHDED,PKC-MU,PKCM,PKD,PRKCM,PRKD1,PKD1,KPCD1,nPKC D1,nPKC mu,nPKCD1,nPKC-D1,nPKCmu,nPKC-mu,PKC,PKC MU,PKCmu,PKD 1,PRKD 1,Protein kinase C mu,Protein kinase C mu type,Protein kinase D,Protein kinase D1,Serine/threonine protein kinase D1,Serine/threonine-protein kinase D1,Activation of protein kinase C (PKC) is one of the earliest events in a cascade that controls a variety of cellular responses, including secretion, gene expression, proliferation, and muscle contraction.PKC isoforms belong to three groups based on calcium dependency and activators. Classical PKCs are calcium-dependent via their C2 domains and are activated by phosphatidylserine (PS), diacylglycerol (DAG), and phorbol esters (TPA, PMA) through their cysteine-rich C1 domains. Both novel and atypical PKCs are calcium-independent, but only novel PKCs are activated by PS, DAG, and phorbol esters. Members of these three PKC groups contain a pseudo-substrate or autoinhibitory domain that binds to substrate-binding sites in the catalytic domain to prevent activation in the absence of cofactors or activators. Control of PKC activity is regulated through three distinct phosphorylation events. Phosphorylation occurs in vivo at Thr500 in the activation loop, at Thr641 through autophosphorylation, and at the carboxy-terminal hydrophobic site Ser660. Atypical PKC isoforms lack hydrophobic region phosphorylation, which correlates with the presence of glutamic acid rather than the serine or threonine residues found in more typical PKC isoforms. The enzyme PDK1 or a close relative is responsible for PKC activation. A recent addition to the PKC superfamily is PKCμ (PKD), which is regulated by DAG and TPA through its C1 domain. PKD is distinguished by the presence of a PH domain and by its unique substrate recognition and Golgi localization. PKC-related kinases (PRK) lack the C1 domain and do not respond to DAG or phorbol esters. Phosphatidylinositol lipids activate PRKs, and small Rho-family GTPases bind to the homology region 1 (HR1) to regulate PRK kinase activity. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 102 kDa
Observed MW: 110 kDa The actual band is not consistent with the expectation.
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UniProt
- Q15139
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途径
- Myometrial Relaxation and Contraction
抗原
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