Recombinant INPPL1 抗体
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北京 101111
Quick Overview for Recombinant INPPL1 抗体 (ABIN7828310)
抗原
See all INPPL1 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant SHIP-2 Monoclonal Antibody
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纯化方法
- Protein A purified
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亚型
- IgG, kappa
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anti-Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) (pTyr1135) antibody
INPPL1 适用: 人, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) (AA 701-800) antibodyINPPL1 适用: 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) (AA 100-310) antibodyINPPL1 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) antibodyINPPL1 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Inositol Polyphosphate Phosphatase-Like 1 (INPPL1) (AA 1159-1258) antibodyINPPL1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 10G6 unconjugated
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应用备注
- WB 1:1000,IHC 1:100,IF 1:50
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- INPPL1 (Inositol Polyphosphate Phosphatase-Like 1 (INPPL1))
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别名
- SHIP-2
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背景
- SHIP,INPPL,INPPL1,OPSMD,SHIP2,5 trisphosphate 5 phosphatase 2,51C protein,5-trisphosphate 5-phosphatase 2,EC 3.1.3.n1,inositol polyphosphate phosphatase like 1,Inositol polyphosphate phosphatase like protein 1,Inositol polyphosphate phosphatase-like protein 1,INPPL-1,Phosphatidylinositol 3,Protein 51C,SH2 domain containing inositol 5' phosphatase 2,SH2 domain-containing inositol 5''-phosphatase 2,SH2 domain-containing inositol phosphatase 2,SHIP-2,SH2-containing inositol phosphatase 1 (SHIP1) is a hematopoietic phosphatase that hydrolyzes phosphatidylinositol-3,4,5-triphosphate to phosphatidylinositol-3,4-bisphosphate. SHIP1 is a cytosolic phosphatase with an SH2 domain in its amino terminus and two NPXY Shc binding motifs in its carboxy terminus. Upon receptor cross-linking, SHIP is first recruited to the membrane junction through binding of its SH2 domain to the phospho-tyrosine in the ITIM motif, followed by tyrosine phosphorylation on the NPXY motif. The membrane relocalization and phosphorylation on the NPXY motif is essential for the regulatory function of SHIP1. Its effect on calcium flux, cell survival, growth, cell cycle arrest, and apoptosis is mediated through the PI3K and Akt pathways. Tyr1021 is located in one of the NPXY motifs in SHIP1, and its phosphorylation is important for SHIP1 function.SHIP2, a homolog of SHIP1, is highly expressed in heart, skeletal muscle and placenta.SHIP2 negatively regulates insulin signaling and polymorphisms in SHIP2 have been linked to hyperglycemia. Recent studies also suggest SHIP2 as a therapeutic target for the treatment of both obesity and type 2 diabetes. Tyr1135 is phosphorylated in human cancer cells. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 139 kDa
Observed MW: 140 kDa The actual band is not consistent with the expectation.
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UniProt
- O15357
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途径
- Platelet-derived growth Factor Receptor Signaling
抗原
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