Recombinant COPS3 抗体
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北京 101111
Quick Overview for Recombinant COPS3 抗体 (ABIN7828134)
抗原
See all COPS3 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant COPS3 Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human COPS3 fragment
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亚型
- IgG, kappa
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应用备注
- WB 1:500-1:1000,IHC 1:50-1:100,IF 1:50
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- COPS3 (COP9 Signalosome Complex Subunit 3 (COPS3))
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别名
- COPS3
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背景
- SGN,Csn,COPS,COPS3,CSN3,SGN3,Constitutive photomorphogenic homolog subunit 3,COP 9 (constitutive photomorphogenic) subunit 3,COP 9 complex homolog subunit 3,COP 9 complex S3,COP 9 complex subunit 3,COP 9 constitutive photomorphogenic homolog subunit 3,COP 9 homolog,COP 9 signalosome complex subunit 3,COP 9 signalosome subunit 3,COP 9 subunit 3,COP9 (constitutive photomorphogenic) subunit 3,COP9 complex homolog subunit 3,COP9 complex S3,COP9 complex subunit 3,COP9 constitutive photomorphogenic homolog subunit 3,COP9 homolog,COP9 signalosome complex subunit 3,COP9 signalosome subunit 3,COP9 subunit 3,COPS 3,CSN 3,JAB 1 containing signalosome subunit 3,JAB1 containing signalosome subunit 3,JAB1-containing signalosome subunit 3,SGN 3,Signalosome subunit 3,Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 44 kDa
Observed MW: 44 kDa
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UniProt
- Q9UNS2
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途径
- Cell Division Cycle
抗原
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