Recombinant CDC25C 抗体
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北京 101111
Quick Overview for Recombinant CDC25C 抗体 (ABIN7828098)
抗原
See all CDC25C 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant Cdc25C Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human Cdc25C fragment
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亚型
- IgG, kappa
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应用备注
- WB 1:500-1:2000
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- CDC25C (Cell Division Cycle 25 Homolog C (S. Pombe) (CDC25C))
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别名
- Cdc25C
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背景
- CDC,PPP1R,CDC25C,CDC25,PPP1R60,Cdc25C is a protein phosphatase responsible for dephosphorylating and activating cdc2, a crucial step in regulating the entry of all eukaryotic cells into mitosis. Cdc25C is constitutively phosphorylated at Ser216 throughout interphase by c-TAK1, while phosphorylation at this site is DNA damage-dependent at the G2/M checkpoint. When phosphorylated at Ser216, Cdc25C binds to members of the 14-3-3 family of proteins, sequestering Cdc25C in the cytoplasm and thereby preventing premature mitosis. The checkpoint kinases Chk1 and Chk2 phosphorylate Cdc25C at Ser216 in response to DNA damage. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 53 kDa
Observed MW: 53 kDa
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UniProt
- P30307
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途径
- Cell Division Cycle, M Phase
抗原
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