Recombinant CD3G 抗体
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北京 101111
Quick Overview for Recombinant CD3G 抗体 (ABIN7828083)
抗原
See all CD3G 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Recombinant CD3G Monoclonal Antibody
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纯化方法
- Protein A purified
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免疫原
- Recombinant human CD3G fragment
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亚型
- IgG, kappa
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应用备注
- WB 1:500-1:1000,IHC 1:500-1:2000,IF 1:50,IP 1:50
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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有效期
- 12 months
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- CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))
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别名
- CD3G
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背景
- T3G,CD3G,T3,CD_antigen: CD3g,CD3g molecule,CD3-GAMMA,IMD17,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain,Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
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分子量
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Calculated MW: 20 kDa
Observed MW: 18-28 kDa The actual band is not consistent with the expectation.
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UniProt
- P09693
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途径
- TCR Signaling, CXCR4-mediated Signaling Events
抗原
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