Recombinant beta-2 Microglobulin 抗体
Our Local Distributor
北京 101111
Quick Overview for Recombinant beta-2 Microglobulin 抗体 (ABIN7828042)
抗原
See all beta-2 Microglobulin (B2M) 抗体抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
原理
- Recombinant beta-2-Microglobulin Monoclonal Antibody
-
纯化方法
- Protein A purified
-
免疫原
- Recombinant human beta-2-Microglobulin fragment
-
亚型
- IgG, kappa
-
-
-
-
应用备注
- WB 1:500-1:2000,IHC 1:500-1:1000
-
限制
- 仅限研究用
-
-
-
浓度
- 1 mg/mL
-
缓冲液
- PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
-
有效期
- 12 months
-
-
- beta-2 Microglobulin (B2M) (beta-2-Microglobulin (B2M))
-
别名
- beta-2-Microglobulin
-
背景
- IMD,Beta-2-microglobulin form pI,CDABP,B2M,IMD43,B2MG,Beta 2 microglobin,Beta 2 microglobulin,Beta 2 microglobulin precursor,Beta chain of mhc class 1 proteins,Beta chain of MHC class I molecules,Beta-2-Microglobulin,Beta-2-microglobulin form pI 5.3,β2M,β2-Microglobulin,CDABP0092,HDCMA22P,β2-microglobulin (B2M) is a principal component of the Major Histocompatibility Complex (MHC) class I molecule, a ternary membrane protein complex that displays fragments derived from proteolyzed cytosolic proteins on the surface of cells for recognition by the surveillance immune system. As an integral component of the MHC class I complex, β2-microglobulin plays a critically important role in immune system function. It has important relevance to cancer biology research, for example, research studies have shown that nearly one-third of diffuse large B cell lymphomas contain mutations that inactivate β2-microglobulin gene function, thereby allowing tumor cells to escape immune detection. In addition, β2-microglobulin has been identified as an amyloid preprotein with collagen-binding affinity, its accumulation in osteoarthritic lesions of long-term dialysis patients is reportedly a contributing factor to the condition known as amyloid osteoarthropathy. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [
-
分子量
-
Calculated MW: 14 kDa
Observed MW: 14 kDa
-
UniProt
- P61769
-
途径
- TCR Signaling, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
-