Recombinant Nipah Virus Post-Fusion Glycoprotein (NIV pF) 抗体
This 小鼠 单克隆 antibody specifically detects Nipah Virus Post-Fusion Glycoprotein in ELISA 和 WB. It exhibits reactivity toward Nipah Virus (NiV).
产品编号 ABIN7824739
发货至:
中国
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Quick Overview for Recombinant Nipah Virus Post-Fusion Glycoprotein (NIV pF) 抗体 (ABIN7824739)
抗原
Nipah Virus Post-Fusion Glycoprotein (NIV pF)
抗体类型
Recombinant Antibody
适用
Nipah Virus (NiV)
宿主
小鼠
克隆类型
单克隆
标记
非结合性
应用范围
ELISA, Western Blotting (WB)
克隆位点
3C3
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Expression System
- HEK293
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原理
- Monoclonal Anti-Nipah Post Fusion glycoprotein Antibody, Human IgG1 (3C3) (MALS verified)
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产品特性
- Monoclonal Anti-Nipah Post Fusion glycoprotein Antibody, Human IgG1 (3C3) is a chimeric monoclonal antibody recombinantly expressed from HEK293, which combines the variable region of a mouse monoclonal antibody with Human constant domain.
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纯化方法
- Protein A purified / Protein G purified
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纯度
- 95% as determined by SDS-PAGE.
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过滤
- 0.22 μm filtered
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亚型
- IgG1, kappa
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应用备注
- ELISA: 0.03-16 ng/ml; Western Blot: 0.05-10 µg/ml
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限制
- 仅限研究用
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状态
- Lyophilized
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缓冲液
- Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.
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注意事项
- Please avoid repeated freeze-thaw cycles.
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储存条件
- -20 °C,-80 °C
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储存方法
- For long term storage, the product should be stored at lyophilized state at -20°C or lower. This product is stable after storage at: -20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution.
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- Nipah Virus Post-Fusion Glycoprotein (NIV pF)
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别名
- Nipah Virus Post-Fusion Glycoprotein
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背景
- Hendra virus (HeV) and Nipah virus (NiV) are henipaviruses discovered in the mid-to late 1990s that possess a broad host tropism and are known to cause severe and often fatal disease in both humans and animals. HeV and NiV infect host cells through the coordinated efforts of two envelope glycoproteins. The G glycoprotein attaches to cell receptors, triggering the fusion (F) glycoprotein to execute membrane fusion. G is a type II homotetrameric transmembrane protein responsible for binding to ephrinB2 or ephrinB3 (ephrinB2/B3) receptors. F is a homotrimeric type I transmembrane protein that is synthesized as a premature F0 precursor and cleaved by cathepsin L during endocytic recycling to yield the mature, disulfide-linked, F1 and F2 subunits. Upon binding to ephrinB2/B3, NiV G undergoes conformational changes leading to F triggering and insertion of the F hydrophobic fusion peptide into the target membrane. Subsequent refolding into the more stable post-fusion F conformation drives merger of the viral and host membranes to form a pore for genome delivery to the cell cytoplasm.
抗原
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