Influenza A Matrix Protein 2 抗体 (Influenza A Virus) (AA 2-60) (Cy3)
Quick Overview for Influenza A Matrix Protein 2 抗体 (Influenza A Virus) (AA 2-60) (Cy3) (ABIN739062)
抗原
See all Influenza A Matrix Protein 2 (M2) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 2-60
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特异性
- This antibody will recognize many Influenza A virus strains
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交叉反应
- Virus
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交叉反应 （详细）
- Influenza A virus
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from Influenza A virus H5N1 Matrix Protein-2
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亚型
- IgG
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- Influenza A Matrix Protein 2 (M2)
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别名
- Influenza A virus Matrix Protein 2
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物质类
- Influenza Protein
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背景
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Synonyms: Avian influenza Matrix Protein-2, Influenza A virus H7N7 H9N2 H13N6 H16N3 H1N1 N2N1 H3N2 H2N2
Background: Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation
抗原
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