CXCR3 抗体 (AA 1-100) (PE)
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- 抗原 See all CXCR3 抗体
- CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
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抗原表位
- AA 1-100
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This CXCR3 antibody is conjugated to PE
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应用范围
- Flow Cytometry (FACS), Western Blotting (WB)
- 特异性
- This antibody is specific for isoform 2: CXCR3B
- 交叉反应
- 人, 小鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human CXCR3 isoform 2
- 亚型
- IgG
- Top Product
- Discover our top product CXCR3 Primary Antibody
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- 应用备注
- FCM 1:20-100
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))
- 别名
- CXCR3 (CXCR3 产品)
- 背景
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Synonyms: GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R, C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CXCR3
Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.
- 基因ID
- 2833
- UniProt
- P49682
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