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CXCR3 抗体 (AA 1-100) (Biotin)

This anti-CXCR3 antibody is a 兔 多克隆 antibody detecting CXCR3 in WB, ELISA, IHC (p) 和 IHC (fro). Suitable for 人 和 小鼠.
产品编号 ABIN739016
发货至: 中国

Quick Overview for CXCR3 抗体 (AA 1-100) (Biotin) (ABIN739016)

抗原

See all CXCR3 抗体
CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

适用

  • 99
  • 46
  • 17
  • 1
人, 小鼠

宿主

  • 86
  • 25
  • 12
  • 1
  • 1

克隆类型

  • 75
  • 50
多克隆

标记

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  • 3
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  • 2
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  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
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  • 1
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This CXCR3 antibody is conjugated to Biotin

应用范围

  • 68
  • 67
  • 38
  • 37
  • 16
  • 15
  • 14
  • 13
  • 13
  • 12
  • 6
  • 2
  • 2
  • 1
  • 1
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  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • 抗原表位

    • 15
    • 8
    • 6
    • 6
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-100

    特异性

    This antibody is specific for isoform 2: CXCR3B

    交叉反应

    人, 小鼠

    纯化方法

    Purified by Protein A.

    免疫原

    KLH conjugated synthetic peptide derived from human CXCR3 isoform 2

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IHC-F 1:100-500

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

    别名

    CXCR3

    背景

    Synonyms: GPR9, MigR, CD182, CD183, Mig-R, CKR-L2, CMKAR3, IP10-R, C-X-C chemokine receptor type 3, CXC-R3, CXCR-3, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, IP-10 receptor, CXCR3

    Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway (PubMed:12782716). Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway (PubMed:12782716). Does not promote cell chemotaxis respons. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.

    基因ID

    2833

    UniProt

    P49682
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