Runx1 + Runx2 (AA 202-300) 抗体
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北京 101111
Quick Overview for Runx1 + Runx2 (AA 202-300) 抗体 (ABIN738156)
抗原
适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 202-300
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交叉反应
- 豚鼠, 人, 小鼠, 兔, 大鼠
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预测反应
- Dog,Cow,Sheep,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human RUNX2
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亚型
- IgG
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "The role of inhibition by phosphocitrate and its analogue in chondrocyte differentiation and subchondral bone advance in Hartley guinea pigs." in: Experimental and therapeutic medicine, Vol. 15, Issue 4, pp. 3320-3328, (2018) (PubMed).
: "Blockade of hypoxia-induced CXCR4 with AMD3100 inhibits production of OA-associated catabolic mediators IL-1β and MMP-13." in: Molecular medicine reports, Vol. 14, Issue 2, pp. 1475-82, (2016) (PubMed).
: "High expression of periostin is dramatically associated with metastatic potential and poor prognosis of patients with osteosarcoma." in: World journal of surgical oncology, Vol. 12, pp. 287, (2014) (PubMed).
: "Contribution of SATB2 to the stronger osteogenic potential of bone marrow stromal cells from craniofacial bones." in: Cell and tissue research, Vol. 350, Issue 3, pp. 425-37, (2013) (PubMed).
: "Expression pattern of embryonic stem cell markers in DFAT cells and ADSCs." in: Molecular biology reports, Vol. 39, Issue 5, pp. 5791-804, (2012) (PubMed).
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- Runx1 + Runx2
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别名
- RUNX1+RUNX2
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背景
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Synonyms: CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1, Runt-related transcription factor 2, Acute myeloid leukemia 3 protein, Core-binding factor subunit alpha-1, Oncogene AML-3, Osteoblast-specific transcription factor 2, Polyomavirus enhancer-binding protein 2 alpha A subunit, PEA2-alpha A, PEBP2-alpha A, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit, RUNX2, PEBP2A
Background: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE) (By similarity). Inhibits KAT6B-dependent transcriptional activation.
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基因ID
- 860
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UniProt
- Q13950
抗原
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