Recombinant CD370 & PD-L1 抗体
The 小鼠 Bispecific anti-CD370 & PD-L1 antibody is suitable to detect CD370 & PD-L1 in samples from 小鼠. It has been validated for ELISA, FACS, ICC, IHC, in vivo 和 WB.
产品编号 ABIN7795542
发货至:
中国
Contact our Customer Service for availability and price in your country.
Contact Info
Our Local Distributor
中国
北京 101111
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
Quick Overview for Recombinant CD370 & PD-L1 抗体 (ABIN7795542)
抗原
CD370 & PD-L1
抗体类型
Recombinant Antibody
适用
小鼠
宿主
小鼠
克隆类型
Bispecific
应用范围
ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), In vivo Studies (in vivo), Western Blotting (WB)
质量等级
In vivo Grade
克隆位点
10B4-10F-9G2-1
-
-
Expression System
- Mammalian cells
-
原理
- In Vivo Grade Recombinant Anti-mouse CD370 / PD-L1 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10B4 / 10F.9G2.1)
-
产品特性
- The rat anti-mouse CD370 (Clec9A or DNGR-1) monoclonal antibody 10B4 (rat IgG2a kappa) reacts with the mouse CD370 protein. CLEC9A (C-type lectin domain family 9 member A), a transmembrane glycoprotein with a single extracellular C-type lectin domain (CTLD), plays a role in the immune response. As an activation receptor, CLEC9A is expressed on myeloid lineage cells, helps process material from dead cells, recognizes filamentous actin when cell membranes are damaged, and helps present antigens to cytotoxic T cells. CLEC9A has an intracellular cytoplasmic tail with potential signaling motifs. CLEC9A is expressed on a subset of BDCA3+ dendritic cells and CD16- monocytes in humans, and is expressed on CD8+ conventional DCs and plasmacytoid DCs in mice. The rat anti-mouse PD-L1 monoclonal antibody 10F.9G2 (rat IgG2b kappa) reacts with the mouse PD-L1 protein (programmed death ligand-1, B7-H1 or CD274), a member of the B7 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 10F.9G2 monoclonal antibody blocks the binding of the mouse PD-L1 protein to the mouse PD-1 protein. It is under investigation how the recombinant anti-mouse CD370 / PD-L1 bispecific antibodies (10B4 / 10F.9G2) behave different from the individual monoclonal antibodies and their combination. Our recombinant anti-mouse CD370 / PD-L1 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse CD370 antibody (hybridoma clone name or number: 10B4) and the rat anti-mouse PD-L1 antibody (hybridoma clone name or number: 10F.9G2).
-
纯化方法
- Protein A or G affinity column
-
纯度
- >95 % by reducing SDS-PAGE
-
内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method
-
亚型
- IgG2c, L234A, L235A, P329G, kappa
-
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- > 3 mg/mL
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
-
-
- CD370 & PD-L1
-
Sub Type
- Bispecific
抗原
-
You are here:
