In vivo Grade Recombinant Anti-human Siglec-2/CD22 Monoclonal Antibody (Clone: NCI m971), Mouse IgG2a Kappa
产品特性
The recombinant NCI m971 antibody binds to the human CD22 protein, a sugar binding transmembrane protein, which specifically binds sialic acid with an immunoglobulin (Ig) domain located at its N-terminus. CD22 functions as an inhibitory receptor for B cell receptor (BCR) signaling. It is also involved in the B cell trafficking to Peyer's patches in mice. In mice, it has been shown that CD22 blockade restores homeostatic microglial phagocytosis in aging brains.