Recombinant Trop2 (Sacituzumab Biosimilar) 抗体
This anti-Trop2 (Sacituzumab Biosimilar) antibody is a Humanized 单克隆 antibody detecting Trop2 (Sacituzumab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant Trop2 (Sacituzumab Biosimilar) 抗体 (ABIN7795133)
抗原
Trop2 (Sacituzumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
Humanized
克隆类型
单克隆
标记
This Trop2 (Sacituzumab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
质量等级
Research Grade
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Expression System
- Mammalian cells
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原理
- Sacituzumab Biosimilar, Endotoxin 0.05 EU/mg
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产品特性
- What is sacituzumab biosimilar research grade? Sacituzumab Biosimilar uses the same protein sequences as the therapeutic antibody sacituzumab. Sacituzumab govitecan is a Trop-2-directed antibody and topoisomerase inhibitor drug conjugate used for the treatment of metastatic triple-negative breast cancer and metastatic urothelial cancer. Triple-negative breast cancer is a type of breast cancer that tests negative for estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) protein. Therefore, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2. Sacituzumab govitecan is a conjugate of the humanized anti-Trop-2 monoclonal antibody linked with SN-38, the active metabolite of irinotecan. Each antibody having on average 7.6 Molecules of SN-38 attached. SN-38 is too toxic to administer directly to patients, but linkage to an antibody allows the drug to specifically target cells containing Trop-2.
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纯化方法
- Protein A or G affinity column
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纯度
- >95 % by reducing SDS-PAGE
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内毒素水平
- Less than 0.5 EU/mg of protein as determined by LAL method
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免疫原
- Human Trop-2
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anti-Trop2 (Sacituzumab Biosimilar) antibody
Research Grade 适用: 人 FACS, ELISA 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- > 3 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- Trop2 (Sacituzumab Biosimilar)
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别名
- Sacituzumab Biosimilar
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物质类
- Biosimilar
抗原
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