Recombinant TAG-72 (Satumomab Biosimilar) 抗体
This anti-TAG-72 (Satumomab Biosimilar) antibody is a Human 单克隆 antibody detecting TAG-72 (Satumomab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant TAG-72 (Satumomab Biosimilar) 抗体 (ABIN7795125)
抗原
TAG-72 (Satumomab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
Human
克隆类型
单克隆
标记
This TAG-72 (Satumomab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
质量等级
Research Grade
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Expression System
- Mammalian cells
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原理
- Satumomab Biosimilar, Anti-human TAG-72 Monoclonal Antibody
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产品特性
- Satumomab Biosimilar uses the same protein sequences as the therapeutic antibody satumomab. Satumomab is a modified mouse monoclonal antibody which could specifically bind to tumor-associated glycoprotein (TAG-72). Satumomab is usually combined with some radioactive elements to diagnose colorectal cancer and ovarian cancer. Satumomab is also used to study the distribution of tumor cell-associated antigens in breast cancer. The original satumomab monoclonal antibody was produced by purifying the membrane enrichment part of human breast cancer biopsy tissue and immunizing mice. In fact, in addition to colorectal and ovarian cancer, satumomab can also interact with a variety of cancer cells, including gastric cancer, pancreatic cancer, endometrial cancer and lung adenocarcinoma. For a variety of normal adult tissues, except secretory endometrium, B72.3 had no effect or only weak response. The characteristic that satumomab can bind to tumor antigen TAG-72 has been used in the clinical study of various cancer detection. Serological tests used satumomab showed that 50 % of cancer patients could be detected TAG-72 and 4 % of the control population could be detected TAG-72. Satumomab is also used to detect embryonic carcinoma and fine needle biopsy in human effusion and as a diagnostic tool to distinguish lung adenocarcinoma from non-small cell lung cancer or malignant mesothelioma. Labeled satumomab-assisted computer scanning is used to study the localization of tumor lesions. The target of satumomab, TAG-72, is a kind of tumor marker with high specificity and few false positive. Because TAG-72 widely exists in all kinds of cancer tissues and has little expression in normal and benign lesions, anti-TAG-72 monoclonal antibody, which uses satumomab as substitute, has been applied to the study of immunohistochemistry and immunocytochemistry. Those monoclonal antibodies have become a useful tool for clinical tumor diagnosis and differential diagnosis.
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纯化方法
- Protein A or G affinity column
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纯度
- >95 % by reducing SDS-PAGE
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method
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免疫原
- Human TAG-72
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亚型
- IgG1, kappa
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anti-TAG-72 (Satumomab Biosimilar) antibody
适用: 人 FACS, BI, IHC 宿主: 小鼠 Monoclonal B72-3 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- > 3 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- TAG-72 (Satumomab Biosimilar)
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别名
- Satumomab Biosimilar
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物质类
- Biosimilar
抗原
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