Recombinant ITGA4 (Natalizumab Biosimilar) 抗体
Quick Overview for Recombinant ITGA4 (Natalizumab Biosimilar) 抗体 (ABIN7795116)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
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Expression System
- Mammalian cells
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原理
- Natalizumab Biosimilar, Integrin alpha 4 Monoclonal Antibody
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产品特性
- Natalizumab Biosimilar uses the same protein sequences as the therapeutic antibody natalizumab. Natalizumab is a monoclonal anti-integrin antibody which binds to the alpha 4 subunit of integrins to prevent migration of immune cells, and is used to treat Crohn's disease or multiple sclerosis. Humanized IgG4k monoclonal antibody produced in murine myeloma cells. Natalizumab contains human framework regions and the complementarity-determining regions of a murine antibody that binds to a4-integrin. Binds to the α4-subunit of α4b 1 and α4b 7 integrins expressed on the surface of all leukocytes except neutrophils, and inhibits the α4-mediated adhesion of leukocytes to their counter-receptor(s).
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纯化方法
- Protein A or G affinity column
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纯度
- >95 % by reducing SDS-PAGE
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method
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免疫原
- Human Integrin alpha 4
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anti-ITGA4 (Natalizumab Biosimilar) antibody
Research Grade 适用: 人 FACS 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-ITGA4 (Natalizumab Biosimilar) antibody适用: 人 FACS, BR 宿主: 兔 Chimeric unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- > 3 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- ITGA4 (Natalizumab Biosimilar)
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别名
- Natalizumab Biosimilar
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物质类
- Biosimilar
抗原
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