Recombinant IL-6R (Tocilizumab Biosimilar) 抗体
Quick Overview for Recombinant IL-6R (Tocilizumab Biosimilar) 抗体 (ABIN7795095)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
质量等级
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Expression System
- Mammalian cells
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原理
- Tocilizumab Biosimilar, Human IL-6R Monoclonal Antibody
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产品特性
- What is tocilizumab biosimilar research grade? Tocilizumab biosimilar uses the same protein sequences as the therapeutic antibody tocilizumab. Tocilizumab is a recombinant humanized monoclonal antibody IL-6 receptor inhibitor used to treat inflammatory and autoimmune conditions. Interleukin 6 (IL-6) is a pro-inflammatory cytokine produced by cells including T-cells, B-cells, lymphocytes, monocytes, fibroblasts. IL-6 rapidly induces C-reactive protein, serum amyloid A, fibrinogen, haptoglobin, and α-1-antichymotrypsin while inhibiting production of fibronectin, albumin, and transferrin. IL-6 also induces antibody production, induces cytotoxic T-cell differentiation, and inhibits regulatory T-cell differentiation. Tocilizumab binds soluble and membrane bound IL-6 receptors, preventing IL-6 mediated inflammation.
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纯化方法
- Protein A or G affinity column
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纯度
- >95 % by reducing SDS-PAGE
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method
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免疫原
- Human IL-6R
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anti-IL-6R (Tocilizumab Biosimilar) antibody
Research Grade 适用: 人 ELISA, FACS 宿主: Humanized Monoclonal unconjugated Recombinant Antibody
anti-IL-6R (Tocilizumab Biosimilar) antibody适用: 人 ELISA, InhA 宿主: 兔 Chimeric RhPM-1 unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- > 3 mg/mL
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储存条件
- 4 °C,-20 °C
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储存方法
- Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.
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- IL-6R (Tocilizumab Biosimilar)
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别名
- Tocilizumab Biosimilar
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物质类
- Biosimilar
抗原
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