Influenza A NS1 抗体
Quick Overview for Influenza A NS1 抗体 (ABIN7794992)
抗原
适用
宿主
克隆类型
标记
应用范围
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原理
- Anti-Avian Influenza Nonstructural Protein 1(H5N1 NS1)
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特异性
- Rabbit Anti-H5N1 NS1 recognizes H5N1 NS1. This polyclonal antibody was purified using affinity chromatography. Background Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals, however, it is in birds that all subtypes, including the so-called ?avian flu? or H5N1, can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. One of the less studied proteins encoded by, but not incorporated in, the influenza virus is the nonstructural protein (NS) 1. NS1 counters cellular antiviral activities and acts as a virulence factor. It can bind to double-stranded RNA and sequester it from 2?-5? OAS, preventing the activation of the RNAse L, which normally acts to degrade RNA and prevent virus replication. NS1 also binds to and inhibits the anti-viral protein kinase PKR.
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限制
- 仅限研究用
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浓度
- 0.5 μg/mL
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缓冲液
- This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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- Influenza A NS1 (NS1) (Influenza Non Structural 1 (NS1))
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别名
- Avian Influenza Nonstructural Protein 1
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物质类
- Influenza Protein
抗原
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