Anthrax Toxin Lethal Factor 抗体 (Internal Region)
This anti-Anthrax Toxin Lethal Factor antibody is a 兔 多克隆 antibody detecting Anthrax Toxin Lethal Factor in . Suitable for Bacillus anthracis.
Quick Overview for Anthrax Toxin Lethal Factor 抗体 (Internal Region) (ABIN7794899)
抗原
Anthrax Toxin Lethal Factor (Lef)
适用
Bacillus anthracis
宿主
兔
克隆类型
多克隆
标记
This Anthrax Toxin Lethal Factor antibody is un-conjugated
应用范围
请咨询
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抗原表位
- Internal Region
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原理
- Anti-Anthrax Lethal Factor (Intermediate Domain)
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特异性
- Rabbit Anti-Anthrax Lethal Factor (Anthrax LF) recognizes an epitope in the intermediate domain of Anthrax LF. This polyclonal antibody was purified using affinity chromatography. Background Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin protective antigen (PA), lethal factor (LF), and edema factor (EF)1,2. PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR)3 and capillary morphogenesis protein 2 (CMG2),4 although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. These toxins are usually sufficient to cause rapid cell death, and often the death of the organism.
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anti-Anthrax Toxin Lethal Factor (Lef) (AA 779-792) antibody
Lef 适用: Bacillus anthracis WB 宿主: 小鼠 Monoclonal unconjugated
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限制
- 仅限研究用
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浓度
- 0.5 μg/mL
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缓冲液
- This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02 % sodium azide as a preservative.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
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- Anthrax Toxin Lethal Factor (Lef)
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别名
- Anthrax Lethal Factor
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背景
- Anthrax Lethal Factor,
抗原
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