PTTG1 抗体 (AA 101-202)
Quick Overview for PTTG1 抗体 (AA 101-202) (ABIN735803)
抗原
See all PTTG1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-202
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Pig,Horse
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human PTTG
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亚型
- IgG
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anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-199) antibody
PTTG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (Internal Region) antibodyVerified PTTG1 适用: 人 ELISA, IHC, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-202) antibodyPTTG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-202) antibodyPTTG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 16-45), (N-Term) antibodyPTTG1 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB18596 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 93-113) antibodyPTTG1 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 1G10 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 2-202) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-100) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 小鼠 Polyclonal unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-100) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1D9 unconjugated
anti-Pituitary Tumor-Transforming 1 (PTTG1) (AA 1-100) antibodyPTTG1 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2C3 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- PTTG1 (Pituitary Tumor-Transforming 1 (PTTG1))
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别名
- Securin/PTTG
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背景
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Synonyms: AW555095, C87862, Cut2, EAP 1, EAP1, ESP1 ASSOCIATED PROTEIN 1, Esp1-associated protein, hPTTG, MGC126883, MGC138276, Pds1, Pituitary tumor transforming 1, Pituitary tumor transforming protein 1, Pituitary tumor-transforming 1, isoform CRA_a, Pituitary tumor-transforming 1, isoform CRA_b, Pituitary tumor-transforming gene 1, Pituitary tumor-transforming gene 1 protein, PTTG 1, PTTG, PTTG1, PTTG1 protein, Pttg3, TUMOR TRANSFORMING 1, Tumor transforming protein 1, TUMOR-TRANSFORMING 1, TUTR 1, TUTR1.
Background: Securin is an anaphase inhibitor and plays an important role in DNA damage and spindle check point pathways. It inhibits sister chromatid separation by binding and inhibiting Esp 1, a cystein protease that causes cleavage of the cohesin Scc 1 that binds the sister chromatids together. It is responsible for targeting of Esp 1 to the nucleus and its binding to the spindle. Degradation of Securin occurs shortly before anaphase, which liberates Esp 1 and is a pre-requisite for anaphase entry. It is targeted for degradation by ubiquitination mediated bycyclosome / anaphase promoting complex (APC)functioning as a ubiquitin ligase. In response to DNA damage Chk 1 phosphorylates Securin to stabilize it against the APC mediated destruction, hence preventing the entry of such a cell into anaphase. Securin is highly expressed in various human tumors, including pituitary, adrenal, kidney, liver, and ovarian tumors, and in cell lines derived from pituitary tumors, breast tumors, endometrial tumors, and ovarian tumors.
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基因ID
- 9232
抗原
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