MMP17 抗体 (AA 101-200)
(1 reference)Quick Overview for MMP17 抗体 (AA 101-200) (ABIN735533)
抗原
See all MMP17 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 101-200
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交叉反应
- 小鼠
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预测反应
- Human,Rat
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human MMP17
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亚型
- IgG
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anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) antibody
MMP17 适用: 人 WB, IHC (p), ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) (AA 432-460), (C-Term) antibodyMMP17 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB33781 unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) (Cleaved-Gln129) antibodyMMP17 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) antibodyMMP17 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) antibodyMMP17 适用: 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) (cleaved), (Gln129) antibodyMMP17 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) (AA 391-420) antibodyMMP17 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB2033-2034 unconjugated
anti-Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17) (Middle Region) antibodyMMP17 适用: 人 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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: "Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy." in: International journal of molecular medicine, Vol. 40, Issue 6, pp. 1781-1791, (2018) (PubMed).
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: "Hydrogen sulfide alleviates myocardial fibrosis in mice with alcoholic cardiomyopathy by downregulating autophagy." in: International journal of molecular medicine, Vol. 40, Issue 6, pp. 1781-1791, (2018) (PubMed).
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- MMP17 (Matrix Metallopeptidase 17 (Membrane-inserted) (MMP17))
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别名
- MMP-17
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背景
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Synonyms: Matrix metalloproteinase-17, MMP-17, MMP17, MTMMP 4, Matrix metalloproteinase 17, Matrix metalloproteinase 17 membrane inserted, Membrane type 4 matrix metalloproteinase, Membrane type matrix metalloproteinase 4, MMP 17, MT MMP 4, MT MMP4, MT4 MMP, MT4MMP.
Background: The matrix metalloproteinases (MMPs) are a family of at least eighteen secreted and membrane bound zincendopeptidases. Collectively, these enzymes can degrade all the components of the extracellular matrix, including fibrillar and non fibrillar collagens, fibronectin, laminin and basement membrane glycoproteins. In general, a signal peptide, a propeptide, and a catalytic domain containing the highly conserved zinc binding site characterizes the structure of the MMPs. In addition, fibronectin like repeats, a hinge region, and a C terminal hemopexin like domain allow categorization of MMPs into the collagenase, gelatinase, stomelysin and membrane type MMP subfamilies. All MMPs are synthesized as proenzymes, and most of them are secreted from the cells as proenzymes. Thus, the activation of these proenzymes is a critical step that leads to extracellular matrix breakdown. MMPs are considered to play an important role in wound healing, apoptosis, bone elongation, embryo development, uterine involution, angiogenesis and tissue remodeling, and in diseases such as multiple sclerosis, Alzheimer's, malignant gliomas, lupus, arthritis, periodontis, glumerulonephritis, atherosclerosis, tissue ulceration, and in cancer cell invasion and metastasis.MMP17 has been reported to be elevated in several tumor cell lines, and is constituitively produced by some normal cell lines. Treatment of cells with Concanavolin A or the phorbol ester TPA stimulates production of MMP17 in some cell types, and the enzyme can be recovered in cell lysates. Shed forms of MMP17 have also been reported.
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基因ID
- 4326
抗原
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