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FOXP3 抗体 (PE-Cy5)

This anti-FOXP3 antibody is a 大鼠 单克隆 antibody detecting FOXP3 in FACS. Suitable for 小鼠 和 大鼠.
产品编号 ABIN7673905
发货至: 中国

Quick Overview for FOXP3 抗体 (PE-Cy5) (ABIN7673905)

抗原

See all FOXP3 抗体
FOXP3 (Forkhead Box P3 (FOXP3))

适用

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小鼠, 大鼠

宿主

  • 99
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  • 21
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大鼠

克隆类型

  • 99
  • 93
单克隆

标记

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This FOXP3 antibody is conjugated to PE-Cy5

应用范围

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Flow Cytometry (FACS)

克隆位点

FJK-16s
  • 原理

    PE-Cy5 Anti-Mouse/Rat Foxp3 Antibody

    纯化方法

    0

    纯度

    0

    亚型

    IgG2a, kappa
  • 应用备注

    Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freeze / thaw cycles.

    储存条件

    4 °C

    储存方法

    2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

    有效期

    12 months
  • 抗原

    FOXP3 (Forkhead Box P3 (FOXP3))

    别名

    Foxp3

    背景

    Synonyms: IPEXJM2ScurfinZinc finger protein JM2|Forkhead box protein P3

    Background: FOXP3 is a 47 kD transcription factor, also known as Forkhead box protein P3, Scurfin, JM2, or IPEX. It is proposed to be a master regulatory gene and more specific marker of T regulatory cells than most cell surface markers (such as CD4 and CD25). Transduced expression of FOXP3 in CD4+/CD25- cells has been shown to induce GITR, CD103, and CTLA4 and impart a T regulatory cell phenotype. FOXP3 is mutated in X-linked autoimmunity-allergic dysregulation syndrome (XLAAD or IPEX) in humans and in "scurfy" mice. Overexpression of FOXP3 has been shown to lead to a hypoactive immune state suggesting that this transcriptional factor is a central regulator of T cell activity.

    分子量

    0

    基因ID

    20371

    UniProt

    Q99JB6

    途径

    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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