SIRPA 抗体 (FITC)
Quick Overview for SIRPA 抗体 (FITC) (ABIN7673078)
抗原
See all SIRPA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- FITC Anti-Human CD172a/b Antibody
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纯化方法
- 0
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纯度
- 0
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亚型
- IgG1, kappa
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应用备注
- Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freeze / thaw cycles.
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储存条件
- 4 °C
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储存方法
- 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)
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有效期
- 12 months
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- SIRPA (Signal-Regulatory Protein alpha (SIRPA))
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别名
- CD172a
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背景
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Synonyms: SIRPa|SIRPb|SIRPalpha/beta|BIT|SHPS1|MFR|P84|PTPNS1|CD172 antigen-like family member A|CD172 antigen-like family member B
Background: CD172a, also known as signal-regulatory protein α (SIRPα), src homology 2 domain-containing phosphatase substrate-1 (SHPS1), PTPNS1, BIT, MFR, and P84, is a 75-110 kD transmembrane glycoprotein involved in receptor tyrosine kinase coupled signaling pathway. It belongs to the Ig superfamily and is primarily expressed on monocytes/macrophages, granulocytes, dendritic cells, and neurons. CD172a serves as a substrate of activated receptor tyrosine kinases (RTKs). The interaction of CD172a intracellular domain with SHP-1 and SHP-2 displays negative signaling in the regulation of leukocyte adhesion and transmigration, T cell activation, macrophage fusion, and phagocytosis. CD47 (IAP) is the extracellular ligand for CD172a. SIRPα was recently demonstrated to be a specifc marker for cardiomyocytes derived from human pluripotent stem cells2.
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分子量
- 0
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基因ID
- 140885
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UniProt
- O00241
抗原
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