NT-proBNP,Nppb,Natriuretic peptides B,Brain natriuretic factor prohormone(preproBNP,preproBNP),Gamma-brain natriuretic peptide,Iso-ANP,Brain natriuretic peptide 45,Brain-type Natriuretic Peptide (BNP) is a nonglycosylated peptide that is produced predominantly by ventricular myocytes and belongs to the natriuretic peptide family. Proteolytic cleavage of the 12 kDa BNP precursor gives rise to N-terminal proBNP (NT-proBNP) and mature BNP. Plasma NT-proBNP is a marker for congestive heart failure,while mature BNP (aa 103 - 134) promotes vasodilation and fluid and sodium excretion.