IFNA1 抗体
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北京 101111
Quick Overview for IFNA1 抗体 (ABIN7670653)
抗原
See all IFNA1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- IFN-alpha 1 Monoclonal Antibody(Detector)
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纯化方法
- Protein A/G Purification
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免疫原
- Recombinant Mouse IFN-alpha 1 protein expressed by Mammalian
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亚型
- IgM
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应用备注
- ELISA Detector 0.1-0.4 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Sterile PBS , pH 7.4
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储存液
- Without preservative
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注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
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有效期
- 12 months
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- IFNA1 (Interferon, alpha 1 (IFNA1))
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别名
- IFN-alpha 1
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背景
- Ifna,IL-1ra Homolog,IFN-α,IL-1F,IL-1L,IL-1HY,IL-1RP,IFN-alpha,FIL1 delta,IFN-alpha-1,IFN-α1,IL-1 delta,IL-1F5,IL-1HY1,IL-1L1,IL-1ra Homolog 1,IL-1RP3,Ifna1,The interferons (IFN) are a family of cytokines with potent antiviral, antiproliferative and immunomodulatory properties, and classified based on their binding specificity to cell surface receptors. The type I IFN bind to the interferon alpha receptor (IFNAR), which consists of two subunits: IFNAR1 ( alpha -subunit) and IFNAR2 ( beta -subunit). This binding contributes to TNF-alpha induced signaling. Both the human and mouse genome code for more than a dozen closely related IFNa subtypes and the varous IFN a share about 80 % sequence homology among them. Interferon-alpha 1 (IFNA1) is a secreted, approximately 19 kDa member of the type I interferon family of molecules. Mature mouse IFN-alpha 1 shares 63 % and 82 % amino acid sequence identity with human and rat IFN-alpha 1, respectively. Low level IFN-alpha is detected under physiological conditions, and the production of IFNs is markedly enhanced during virus infection. Although originally discovered by its capability to fight virus replication, IFN-alpha functions as a prototypic tumor suppressor that represses the clinical tumorigenic phenotype in some malignancies.
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UniProt
- P01572
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途径
- JAK/STAT Signaling, Hepatitis C
抗原
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