DPP4 抗体
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北京 101111
Quick Overview for DPP4 抗体 (ABIN7670590)
抗原
See all DPP4 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- DPPIV/CD26 Polyclonal Antibody(Capture/Detector)
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纯化方法
- Antigen Affinity Purification
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免疫原
- Recombinant Human DPPIV/CD26 protein expressed by Mammalian
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亚型
- IgG
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应用备注
- ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Sterile PBS , pH 7.4
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储存液
- Without preservative
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注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
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有效期
- 12 months
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- DPP4 (Dipeptidyl-Peptidase 4 (DPP4))
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别名
- DPPIV/CD26
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背景
- Dipeptidyl peptidase 4,ADABP,Adenosine deaminase complexing protein 2 (ADCP-2),Dipeptidyl peptidase IV (DPP IV),T-cell activation antigen CD26,TP103,CD26,DPP4,ADCP2,CD26,CD26 is a signal-anchor for type II membrane protein that belongs to the peptidase S9B family. CD26 is expressed specifically in lymphatic vessels but not in blood vessels in the skin, small intestine, esophagus, ovary, breast and prostate glands. It acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC. It's binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner. Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion. In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM. It may be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation. When overexpressed, it enhanced cell proliferation, a process inhibited by GPC3. It acts also as a serine exopeptidase with a dipeptidyl peptidase activity that regulates various physiological processes by cleaving peptides in the circulation, including many chemokines, mitogenic growth factors, neuropeptides and peptide hormones.
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UniProt
- P27487
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途径
- Peptide Hormone Metabolism, Regulation of Leukocyte Mediated Immunity
抗原
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