Cortisol Binding Globulin 抗体
This anti-Cortisol Binding Globulin antibody is a 兔 多克隆 antibody detecting Cortisol Binding Globulin in WB, ELISA 和 IF. Suitable for 人 和 小鼠.
Quick Overview for Cortisol Binding Globulin 抗体 (ABIN7670581)
抗原
Cortisol Binding Globulin
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This Cortisol Binding Globulin antibody is un-conjugated
应用范围
Western Blotting (WB), ELISA, Immunofluorescence (IF)
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原理
- Cortisol Binding Globulin/CBG/SERPINA6 Polyclonal Antibody(Capture/Detector)
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纯化方法
- Antigen Affinity Purification
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免疫原
- Recombinant Human Cortisol Binding Globulin/CBG/SERPINA6 SERPINA6 Protein expressed by Mammalian
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亚型
- IgG
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anti-Cortisol Binding Globulin (Center) antibody
适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500-1:1000,IF 1:50-1:200,ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL
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限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Sterile PBS , pH 7.4
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储存液
- Without preservative
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注意事项
- Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C Valid for 1 month or -20°C Valid for 12 months
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有效期
- 12 months
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- Cortisol Binding Globulin
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背景
- Corticosteroid-binding gLobuLin,CBG,Serpin A6,Transcortin,SERPINA6,CBG,Corticosteroid-binding globulin (CBG),also known as SerpinA6,is a non-inhibitory member of the serine proteinase inhibitor (serpin) superfamily. It is the high-affinity transport protein for glucocorticoids in vertebrate blood. CBG is specifically cleaved by this protease at a precise site close to its carboxy-terminus. This induces a conformation change and disrupts the binding between glucocorticoids and CBG,and promotes a significant and local release of glucocorticoids (over 90 % of them are bound to CBG in human plasma). In this context,CBG directs glucocorticoids to sites of inflammation,and plays in consequence a crucial role in efficient glucocorticoid action in physiology. The SerpinA6 protein is mainly secreted by the liver. This negative acute phase protein regulates free cortisol levels in the blood and distributes cortisol to its target tissues. SerpinA6 deficiency is an extremely rare hereditary disorder characterized by reduced corticosteroid-binding capacity with normal or low plasma corticosteroid-binding globulin concentration,and normal or low basal cortisol levels associated with hypo-/hypertension and muscle fatigue. There are three heritable,human CBG gene mutations that can reduce CBG-cortisol binding affinity and/or reduce circulating CBG levels.
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分子量
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Calculated MW: 45kDa
ObservedMW: 60kDa
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UniProt
- P08185
抗原
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