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VTCN1 抗体 (CF®647)

This anti-VTCN1 antibody is a 小鼠 单克隆 antibody detecting VTCN1 in IHC 和 IHC (fp). Suitable for 人.
产品编号 ABIN7661776
发货至: 中国

Quick Overview for VTCN1 抗体 (CF®647) (ABIN7661776)

抗原

See all VTCN1 抗体
VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This VTCN1 antibody is conjugated to CF®647

应用范围

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Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

克隆位点

VISTA-3007
  • 原理

    VISTA / B7-H5 / VSIR (Negative Regulator of Immune Response)(VISTA/3007), CF647 conjugate

    产品特性

    VISTA / GI24 is a transmembrane protein expressed in bone, on embryonic stem cells (ESCs), and on tumor cell surfaces. On ESC s, Gi24 appears to positively interact with BMP-4, potentiating BMP signaling and the transition from an undifferentiated to a differentiated state. On tumor cells, Gi24 both promotes MT1-MMP expression and activity and serves as a substrate for MT1-MMP. This increases the potential for cell motility. Mature human Gi24 contains a 162aa extracellular region with one V-type Ig-like domain and a 96aa cytoplasmic domain. Human Gi24 undergoes proteolytic cleavage by MT1-MMP, generating a soluble 30 kDa extracellular fragment plus a 25-30 kDa membrane-bound fragment. VISTA is a negative checkpoint regulator and is expressed on myeloid cells, T-cells and human TILs (tumor infiltrating lymphocytes) on MDSCs (myeloid-derived suppressor cells) in the TME (tumor microenvironment). It is very likely both a ligand and receptor and is a promising target for cancer immunotherapy. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Recombinant full-length human VISTA protein

    亚型

    IgG2b, kappa
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    说明

    Positive Control: Spleen or Placenta.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.1 mg/mL

    缓冲液

    PBS, 0.1 % BSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Protect from light

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Protect from light

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

    别名

    B7-H5

    背景

    Synonyms: B7H5, DD1alpha, GI24, PD-1H, PDCD1 homolog, Platelet receptor Gi24, PP2135, Stress-induced secreted protein 1 (SISP1), V domain Ig suppressor of T cell activation (VISTA), V Set Immuno-Regulatory Receptor

    Gene Symbol: VSIR

    分子量

    34 kDa

    基因ID

    64115

    UniProt

    Q9H7M9
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