TGF-beta 抗体 (CF®740)
Quick Overview for TGF-beta 抗体 (CF®740) (ABIN7660691)
抗原
See all TGF-beta (TGFb) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- TGF-beta(1D11.16.8), CF740 conjugate
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产品特性
- This MAb recognizes TGF beta 1, 2 and 3. Three TGF-betas have been identified in mammals. TGF-beta1, TGF-beta2 and TGF-beta3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF-beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF-beta3 protein has approximately 80 % identity to the mature region of both TGF-beta1 and TGF-beta2. However, the NH2 terminals or precursor regions of their molecules share only 27 % sequence identity. TGF-beta's inhibit the growth of epithelial cells and stimulate the growth of mesenchymal cells.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Bovine TGF-beta2 protein
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亚型
- IgG1, kappa
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anti-TGF-beta (TGFb) (AA 301-350) antibody
TGFb 适用: 人, 小鼠, 大鼠, 兔, 绵羊 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, Cow, 兔, 绵羊, Mink, Mustelid WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal TB21 unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, 兔, 哺乳动物 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TGF-beta (TGFb) antibodyTGFb 适用: 人, 小鼠, 大鼠, Cow, 犬, Hamster, 猴 ELISA, Func, D, ELISA (Capture) 宿主: 小鼠 Monoclonal TGFB-510 unconjugated
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应用备注
- Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Cytokine neutralization or functional assay, order Ab without BSA/azide. Optimal dilution for a specific application should be determined by user
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说明
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Positive Control: Salivary gland carcinoma
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % rBSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- TGF-beta (TGFb)
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别名
- TGF-Beta
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背景
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Synonyms: GP40, Leu9, p41, T-cell leukemia antigen, T-cell surface antigen Leu-9, Tp40, TP41
Gene Symbol: TGFB1
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分子量
- ~13 kDa
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基因ID
- 7040
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途径
- EGFR Signaling Pathway, Cellular Response to Molecule of Bacterial Origin, Stem Cell Maintenance, Glycosaminoglycan Metabolic Process, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Ribonucleoside Biosynthetic Process, Skeletal Muscle Fiber Development, Regulation of Carbohydrate Metabolic Process, Protein targeting to Nucleus
抗原
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