SCCA1 抗体 (CF®640R)
This anti-SCCA1 antibody is a 小鼠 单克隆 antibody detecting SCCA1 in WB. Suitable for 人.
Quick Overview for SCCA1 抗体 (CF®640R) (ABIN7660237)
抗原
See all SCCA1 抗体
SCCA1
(Squamous Cell Carcinoma Antigen 1 (SCCA1))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This SCCA1 antibody is conjugated to CF®640R
应用范围
Western Blotting (WB)
克隆位点
CPTC-SERPINB3-2
-
-
原理
- Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), CF640R conjugate
-
产品特性
- Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
-
免疫原
- Recombinant human full-length SERPINB3 protein
-
亚型
- IgG1, kappa
-
-
-
-
应用备注
- Western blot 0.5-1.0 μg/mL, Optimal dilution for a specific application should be determined.
-
说明
-
Positive Control: U-2197, HaCaT, Squamous cells. Expressed in some hepatocellular carcinoma.
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Protect from light
-
储存条件
- 4 °C
-
储存方法
-
Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
-
有效期
- 24 months
-
-
- SCCA1 (Squamous Cell Carcinoma Antigen 1 (SCCA1))
-
别名
- Squamous Cell Carcinoma Antigen 1
-
背景
-
Synonyms: HsT1196, Protein T4 A, Protein T4-A, SCC, SCCA-PD, SCCA1, SCCAPD, Serine (or cysteine) proteinase inhibitor clade B (ovalbumin) member 3, Serpin B3, SERPINB3, Squamous cell carcinoma antigen 1, T4 A, T4-A
Gene Symbol: SERPINB3
-
分子量
- 39 kDa
-
基因ID
- 6317
-
UniProt
- P29508
抗原
-
You are here:
