ROR gamma 抗体 (CF®568)
Quick Overview for ROR gamma 抗体 (CF®568) (ABIN7659666)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- ROR-gamma / RORC (RAR-related Orphan Receptor C)(RORC/2942), CF568 conjugate
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产品特性
- This MAb recognizes a protein of 63 kDa, identified as ROR-C. Its epitope maps in between aa1-50. The nuclear orphan receptors ROR and ROR are members of the nuclear hormone receptor superfamily. Members of this family act by directly associating with DNA sequences known as hormone response elements (HREs) and typically bind DNA as either homo- or heterodimers. RORalpha and RORgamma are unique in that they bind DNA as monomers. RORalpha has multiple isoforms that share common DNA and putative ligand-binding domains, but differ in their amino terminal domains, which are generated by alternative RNA processing. RORgamma comprises a 560 amino acid protein that shares 50 % amino acid identity with RORalpha and is most highly expressed in skeletal muscle. Although these proteins are considered orphan receptors, due to a lack of defined ligands, experimental evidence has shown that melatonin may be the natural ligand for these nuclear receptors. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human RORC protein
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亚型
- IgG2a, kappa
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anti-ROR gamma (Internal Region) antibody
适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma (Internal Region) antibody适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma (Center) antibody适用: 人, 小鼠, Cow, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-ROR gamma antibody适用: 人 IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: Human Lymphocytes. Liver or skeletal muscle tissue.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- ROR gamma
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别名
- ROR-Gamma
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背景
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Synonyms: Nuclear receptor ROR-gamma, Nuclear receptor RZR-gamma, Nuclear receptor subfamily 1 group F member 3 (NR1F3), RAR related orphan receptor C, Retinoid-related orphan receptor-gamma (RORG), Rorc, RZR GAMMA, RZRG, TOR
Gene Symbol: RORC
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分子量
- 63 kDa
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基因ID
- 6097
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UniProt
- P51449
抗原
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