Peroxiredoxin 4 抗体 (CF®647)
Quick Overview for Peroxiredoxin 4 抗体 (CF®647) (ABIN7658577)
抗原
See all Peroxiredoxin 4 (PRDX4) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Peroxiredoxin 4 (Prognostic Marker for Lung SqCC)(CPTC-PRDX4-2), CF647 conjugate
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产品特性
- The peroxiredoxin (PRX) family comprises six antioxidant proteins, PRX I, II, III, IV, V and VI, which protect cells from reactive oxygen species (ROS) by preventing the metal-catalyzed oxidation of enzymes. The PRX proteins primarily utilize thioredoxin as the electron donor for antioxidation, although they are fairly promiscuous with regard to the hydroperoxide substrate. In addition to protection from ROS, peroxiredoxins are also involved in cell proliferation, differentiation and gene expression. PRX I, II, IV and VI show diffuse cytoplasmic localization, while PRX III and V exhibit distinct mitochondrial localization. The human PRX IV gene is expressed in many tissues. It exists as a precursor protein, which is only detected in testis, and aprocessed secreted form. PRX IV is highly expressed in lung cancer and is necessary for the promotion of lung cancer in vitro. Studies have demonstrated that PRX IV positive expression is significantly correlated with recurrences and shorter disease-free survival in patients with early-stage lung squamous cell carcinoma, and therefore can be used as a prognostic marker in lung squamous cell carcinoma. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human PRDX4 protein
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亚型
- IgG2b, kappa
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anti-Peroxiredoxin 4 (PRDX4) (AA 1-271) antibody
PRDX4 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) antibodyPRDX4 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 178-2081), (C-Term) antibodyPRDX4 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 6-249) antibodyPRDX4 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 14-258) antibodyPRDX4 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 51-150) antibodyPRDX4 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 2C12 unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 38-271) antibodyPRDX4 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 82-110) antibodyPRDX4 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB20891 unconjugated
anti-Peroxiredoxin 4 (PRDX4) (AA 89-118), (Middle Region) antibodyPRDX4 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Peroxiredoxin 4 (PRDX4) antibodyPRDX4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: HepG2, HeLa and Jurkat cell lysates. Ovarian carcinoma tissue.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Peroxiredoxin 4 (PRDX4)
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别名
- Peroxiredoxin 4
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背景
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Synonyms: Antioxidant enzyme AOE372, EC 1.11.1.15, Thioredoxin dependent peroxide reductase A0372, TRANK
Gene Symbol: PRDX4
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分子量
- 27 kDa
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基因ID
- 10549
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UniProt
- Q13162
抗原
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