Recombinant HLA DQ 抗体
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北京 101111
Quick Overview for Recombinant HLA DQ 抗体 (ABIN7657100)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- HLA-DQ (MHC II)(rSPV-L3)
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产品特性
- Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons, exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This MAb strongly blocks cytotoxicity activity of T4-positive cytotoxic T cell clones. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- T4-positive CTL clone HG-38
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亚型
- IgG1, kappa
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anti-MHC Class II HLA-DQ (HLA-DQ) antibody
HLA-DQ 适用: 人, Pig FACS, IF, IHC 宿主: 兔 Monoclonal HLA-DQA1-2866R unconjugated Recombinant Antibody
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人, Pig FACS, IF 宿主: 小鼠 Monoclonal SPV-L3 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人, Pig FACS, IF, ELISA 宿主: 小鼠 Monoclonal SPM422 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B-K27 unconjugated
anti-MHC Class II HLA-DQ (HLA-DQ) antibodyHLA-DQ 适用: 人 FACS, IP 宿主: 小鼠 Monoclonal B-K27 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: Raji cells. Tonsil or lymph node
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, no BSA, no azide
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Store at -20 °C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- HLA DQ (HLA-DQ) (MHC Class II HLA-DQ (HLA-DQ))
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别名
- HLA-DQ
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背景
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Synonyms: CELIAC1, DC 4 alpha chain Gluten sensitive enteropathy (celiac disease) (GSE), HLA class II histocompatibility antigen DQ(1) alpha chain, HLA class II histocompatibility antigen DQ(3) alpha chain, IDDM1, Leucocyte antigen DQA1, Major histocompatibility complex class II DQ alpha 1 (HLA DQA1), Major histocompatibility complex class II DQ beta 1 (HLA DQB1), MHC class II antigen HLA DQ beta 1, MHC class II HLA DQ alpha 1, MHC class II HLA DQ beta glycoprotein
Gene Symbol: HLA-DQ
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分子量
- 60 kDa
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基因ID
- 3117, 3118, 3119
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UniProt
- P01908, P01909, P01920
抗原
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