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CEBPA 抗体 (AA 251-358)

Name: CEBPA 抗体 (AA 251-358)
SKU: ABIN732233
Availability: OutOfStock

This anti-CEBPA antibody is a 兔多克隆 antibody detecting CEBPA in WB, ELISA, FACS, IHC (p), IF (cc), IF (p) 和 IHC (fro). Suitable for 人和大鼠.

Formalin-fixed and paraffin embedded rat pancreas labeled with Anti-CEBP-alpha Polyclonal Antibody, Unconjugated (ABIN732233) followed by conjugation to the secondary antibody and DAB staining (CEBPA 抗体 (AA 251-358))

IHC

1 image

产品编号 ABIN732233

发货至: 中国

Quick Overview for CEBPA 抗体 (AA 251-358) (ABIN732233)

抗原

See all CEBPA 抗体

CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))

适用

人, 大鼠

宿主

兔

克隆类型

多克隆

标记

This CEBPA antibody is un-conjugated

应用范围

Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Discover our top product CEBPA Primary Antibody

抗原表位
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AA 251-358

特异性

Due to the similarity in amino acid composition of this protein and the closely related CEBP-beta, this antibody may be cross-react with this protein due to a 77 % non-sequential sequence similarity.

交叉反应

人, 大鼠

预测反应

Mouse,Dog,Cow,Pig,Rabbit

纯化方法

Purified by Protein A.

免疫原

KLH conjugated synthetic peptide derived from human CEBP-alpha

亚型

IgG
anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) antibody
CEBPA 适用: 人 WB, ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 5B7 unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) antibody
CEBPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, FACS, IF/ICC 宿主: 小鼠 Monoclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (pSer21) antibody
CEBPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (AA 1-205) antibody
CEBPA 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (pThr226) antibody
CEBPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (AA 288-337) antibody
CEBPA 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, Pig, 犬, 兔, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (N-Term) antibody
CEBPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (N-Term) antibody
KO Validated CEBPA 适用: 人 WB, IHC (p), IP, ChIP 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) (Middle Region) antibody
CEBPA 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 豚鼠, 犬, 兔, 马, 绵羊 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA) antibody
CEBPA 适用: 人 WB, FACS, EIA 宿主: 小鼠 Monoclonal 4-00E-010 unconjugated

应用备注

WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

限制

仅限研究用
状态

Liquid

浓度

1 μg/μL

缓冲液

0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

储存液

ProClin

注意事项

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

储存条件

4 °C,-20 °C

储存方法

Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

有效期

12 months
抗原

CEBPA (CCAAT/enhancer Binding Protein (C/EBP), alpha (CEBPA))

别名

CEBP-alpha

背景

Synonyms: CEBP, C/EBP-alpha, CCAAT/enhancer-binding protein alpha, C/EBP alpha, CEBPA
Background: Transcription factor that coordinates proliferation arrest and the differentiation of myeloid progenitors, adipocytes, hepatocytes, and cells of the lung and the placenta. Binds directly to the consensus DNA sequence 5'-T[TG]NNGNAA[TG]-3' acting as an activator on distinct target genes (PubMed:11242107). During early embryogenesis, plays essential and redundant functions with CEBPB. Essential for the transition from common myeloid progenitors (CMP) to granulocyte/monocyte progenitors (GMP). Critical for the proper development of the liver and the lung (By similarity). Necessary for terminal adipocyte differentiation, is required for postnatal maintenance of systemic energy homeostasis and lipid storage (By similarity). To regulate these different processes at the proper moment and tissue, interplays with other transcription factors and modulators. Downregulates the expression of genes that maintain cells in an undifferentiated and proliferative state through E2F1 repression, which is critical for its ability to induce adipocyte and granulocyte terminal differentiation. Reciprocally E2F1 blocks adipocyte differentiation by binding to specific promoters and repressing CEBPA binding to its target gene promoters. Proliferation arrest also depends on a functional binding to SWI/SNF complex (PubMed:14660596). In liver, regulates gluconeogenesis and lipogenesis through different mechanisms. To regulate gluconeogenesis, functionally cooperates with FOXO1 binding to IRE-controlled promoters and regulating the expression of target genes such as PCK1 or G6PC. To modulate lipogenesis, interacts and transcriptionally synergizes with SREBF1 in promoter activation of specific lipogenic target genes such as ACAS2. In adipose tissue, seems to act as FOXO1 coactivator accessing to ADIPOQ promoter through FOXO1 binding sites (By similarity).

基因ID

1050

UniProt

P49715

途径

Brown Fat Cell Differentiation, Positive Regulation of fat Cell Differentiation