GNRHR 抗体 (N-Term) (CF®740)
Quick Overview for GNRHR 抗体 (N-Term) (CF®740) (ABIN7654637)
抗原
See all GNRHR 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-29, N-Term
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原理
- GnRH-Receptor (LHRH Receptor)(A9E4), CF740 conjugate
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产品特性
- Recognizes an epitope on the extracellular domain of gonadotropin releasing hormone (GnRH) receptor or luteinizing hormone receptor (LHCGR). Lutropin (also designated luteinizing hormone) plays a role in spermatogenesis and ovulation by stimulating the testes and ovaries to produce steroids. Gonadotropin (also designated choriogonadotropin) production in the placenta maintains estrogen and progesterone levels during the first trimester of pregnancy. Ovaries and testes abundantly express luteinizing hormone/choriogonadotropin receptor. GnRH receptor contains seven hydrophobic transmembrane domains connected by hydrophilic extracellular and intracellular loops characteristic of G-protein coupled receptors. GnRH stimulates the gonadotrophs of the anterior pituitary to secrete luteinizing hormone (LH) as well as follicle-stimulating hormone (FSH). GnRH influences the protective effect of pregnancy and Gonadotropin against breast cancer. The expression of GnRH on breast carcinoma correlates in part to the degree of tumor differentiation. GnRH-positive breast tumors occur more frequently in tumors with greater cell differentiation in premenopausal women. GnRH is present in luteal and granulosa cells as well as in ovarian cell membrane preparations.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- A synthetic peptide aa 1-29 (MANSASPEQNQHCSAINNSIPLMQGNLPY) from the N-terminal of human GnRH receptor.
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亚型
- IgG1, kappa
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anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) (AA 201-328) antibody
GNRHR 适用: 人, 大鼠 WB, ELISA, IHC (p), IHC (fro), ICC, IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) antibodyGNRHR 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) antibodyGNRHR 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) (Internal Region) antibodyVerified GNRHR 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) (N-Term) antibodyGNRHR 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gonadotropin-Releasing Hormone Receptor (GNRHR) (AA 3-13), (Extracellular) antibodyGNRHR 适用: 大鼠 WB, IF, FACS, IHC, LCI 宿主: 兔 Polyclonal unconjugated
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应用备注
- Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunofluorescence: 1-2 μg/mL. Flow Cytometry 0.5-1 μg/million cells/0.1 mL. Predicted to react with pig or rabbit, others not known. Optimal dilution for a specific application should be determined by user
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说明
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Positive Control: T47D cells. Pituitary gland, ovarian or breast cancers.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % rBSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- GNRHR (Gonadotropin-Releasing Hormone Receptor (GNRHR))
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别名
- GnRH Receptor
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背景
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Synonyms: GnRH receptor, GnRH-R, GNRHR1, gonadotropin-releasing hormone (type 1) receptor 1, GRHR, HH7, leutinizing-releasing hormone receptor, LHRHR, LRHR, luliberin receptor, luteinizing hormone releasing hormone receptor, Type I GnRH receptor
Gene Symbol: GNRHR, LHCGR
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分子量
- 54-60 kDa
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基因ID
- 2798
抗原
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