Emerin 抗体 (AA 56-167) (CF®740)
Quick Overview for Emerin 抗体 (AA 56-167) (CF®740) (ABIN7653449)
抗原
See all Emerin (EMD) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 56-167
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原理
- Emerin (Papillary Thyroid Carcinoma and EDMD Marker) (EMD/2168), CF740 conjugate
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产品特性
- Emerin is a member of the nuclear lamina associated protein family. It is ubiquitously expressed and localized to the nuclear membrane in normal cells. Mutations of the gene that encodes emerin result in the X-linked recessive disease Emery-Dreifuss muscular dystrophy (EDMD), which is characterized by slowly progressing contractures, skeletal muscle wasting and cardiomyopathy. Reportedly, lack of Emerin expression is one cause of EDMD. Emerin is involved in the association of the nuclear membrane with the lamina, and is localized specifically to desmosomes and fasciae adherents in the heart. Identification of nuclear membrane irregularities with anti-emerin antibody has been reported useful in diagnosing papillary thyroid carcinoma.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant human Emerin protein fragment (around aa 56-167)
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亚型
- IgG2b, kappa
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anti-Emerin (EMD) (AA 56-167) antibody
EMD 适用: 人 WB, IHC, StM 宿主: 小鼠 Monoclonal EMD-2168 unconjugated
anti-Emerin (EMD) (AA 56-167) antibodyEMD 适用: 人 WB, IHC, IF, StM 宿主: 小鼠 Monoclonal EMD-2167 unconjugated
anti-Emerin (EMD) (AA 1-222) antibodyEMD 适用: 人 ELISA, IHC, FACS, ICC 宿主: 小鼠 Monoclonal 8F5A8 unconjugated
anti-Emerin (EMD) (AA 1-222) antibodyEMD 适用: 人 WB, ELISA, IHC, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Emerin (EMD) (AA 1-110) antibodyEMD 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3B9 unconjugated
anti-Emerin (EMD) (AA 1-254) antibodyEMD 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Emerin (EMD) (AA 1-220) antibodyEMD 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Emerin (EMD) antibodyEMD 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Emerin (EMD) (AA 1-188) antibodyEMD 适用: 人, 兔 WB, IF, ICC 宿主: 小鼠 Monoclonal MANEM1(5D10) unconjugated
anti-Emerin (EMD) (AA 114-183) antibodyEMD 适用: 小鼠, 大鼠, Hamster WB, IF, ICC, EM 宿主: 绵羊 Polyclonal unconjugated
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应用备注
- Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 1-2 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user
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说明
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Positive Control: K-562, HeLa or Jurkat cells. Kidney or Skin
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % rBSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Emerin (EMD)
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别名
- Emerin
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背景
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Synonyms: EMD, Emerin, Emery Dreifuss muscular dystrophy (EDMD), STA
Gene Symbol: EMD
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分子量
- 37 kDa
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基因ID
- 2010
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UniProt
- P50402
抗原
-
