Desmoglein 3 抗体 (AA 379-491) (CF®640R)
Quick Overview for Desmoglein 3 抗体 (AA 379-491) (CF®640R) (ABIN7653124)
抗原
See all Desmoglein 3 (DSG3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 379-491
-
原理
- Desmoglein-3 (Squamous Cell Marker)(DSG3/2837), CF640R conjugate
-
产品特性
- Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
-
免疫原
- Recombinant fragment (around aa 379-491) human DSG3 protein
-
亚型
- IgG1, kappa
-
-
anti-Desmoglein 3 (DSG3) (AA 55-159) antibody
DSG3 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6G2C11 unconjugated
anti-Desmoglein 3 (DSG3) (AA 379-491) antibodyDSG3 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DSG3-2840 unconjugated
anti-Desmoglein 3 (DSG3) (AA 858-999) antibodyDSG3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 379-491) antibodyDSG3 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-543M unconjugated
anti-Desmoglein 3 (DSG3) (AA 50-75) antibodyDSG3 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 70-615) antibodyDSG3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 379-491) antibodyDSG3 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal DSG3-2796 unconjugated
anti-Desmoglein 3 (DSG3) antibodyDSG3 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal 5G11 unconjugated
anti-Desmoglein 3 (DSG3) antibodyDSG3 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 334-604) antibodyDSG3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated
-
-
应用备注
- Optimal working dilution should be determined by the investigator.
-
说明
-
Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 0.1 mg/mL
-
缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
注意事项
- Protect from light
-
储存条件
- 4 °C
-
储存方法
-
Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
-
有效期
- 24 months
-
-
- Desmoglein 3 (DSG3)
-
别名
- Desmoglein-3
-
背景
-
Synonyms: 130 kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)
Gene Symbol: DSG3
Tissue Expression: Epidermal cells
-
分子量
- 130 kDa
-
基因ID
- 1830
-
UniProt
- P32926
抗原
-
