Desmoglein 3 抗体 (AA 379-491) (CF®640R)
Quick Overview for Desmoglein 3 抗体 (AA 379-491) (CF®640R) (ABIN7653123)
抗原
See all Desmoglein 3 (DSG3) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 379-491
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原理
- Desmoglein-3 (Squamous Cell Marker)(DSG3/2796), CF640R conjugate
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产品特性
- Recognizes a protein of 130 kDa, identified as Desmoglein-3 (DSG3). This MAb is highly specific to Desmoglein-3 and does not cross-react with other members of the Desmoglein-family. DSG3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Research has shown that DSG3 has a very high sensitivity (80 % ) and specificity (100 %) in recognizing squamous cell carcinoma (SqCC). Therefore, DSG3 is considered a very important marker for lung SqCC and can be a useful ancillary marker to separate SqCC from other subtypes of lung cancer. Moreover, studies have shown that DSG3 expression in lung SqCC may indicate a poor prognosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant fragment (around aa 379-491) human DSG3 protein
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亚型
- IgG2b, kappa
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anti-Desmoglein 3 (DSG3) (AA 55-159) antibody
DSG3 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6G2C11 unconjugated
anti-Desmoglein 3 (DSG3) (AA 379-491) antibodyDSG3 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal DSG3-2840 unconjugated
anti-Desmoglein 3 (DSG3) (AA 858-999) antibodyDSG3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 379-491) antibodyDSG3 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-543M unconjugated
anti-Desmoglein 3 (DSG3) (AA 50-75) antibodyDSG3 适用: 小鼠, 大鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 70-615) antibodyDSG3 适用: 人 IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 379-491) antibodyDSG3 适用: 人 WB, ELISA, Coat 宿主: 小鼠 Monoclonal DSG3-2796 unconjugated
anti-Desmoglein 3 (DSG3) antibodyDSG3 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal 5G11 unconjugated
anti-Desmoglein 3 (DSG3) antibodyDSG3 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Desmoglein 3 (DSG3) (AA 334-604) antibodyDSG3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C5 unconjugated
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: A431 cells. Skin or Lung Squamous Cell Carcinoma (SCC).
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Desmoglein 3 (DSG3)
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别名
- Desmoglein-3
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背景
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Synonyms: 130 kDa pemphigus vulgaris antigen (PVA), Balding (Bal), Cadherin family member 6 (CDHF6), Desmoglein-3 (DSG3)
Gene Symbol: DSG3
Tissue Expression: Epidermal cells
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分子量
- 130 kDa
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基因ID
- 1830
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UniProt
- P32926
抗原
-
