Chp2 抗体 (CF®488A)
Quick Overview for Chp2 抗体 (CF®488A) (ABIN7652374)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Calcineurin B homologous protein 2 / HCC Antigen 520(CPTC-CHP2-1), CF488A conjugate
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产品特性
- Calcineurin B homologous protein 2, also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na/H exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant human full-length CHP2 protein
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亚型
- IgG2c, kappa
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anti-Chp2 antibody
适用: 人 WB, IF 宿主: 小鼠 Monoclonal CPTC-CHP2-1 unconjugated
anti-Chp2 (Internal Region) antibody适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (AA 101-150) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Center) antibody适用: 人, 小鼠, 大鼠, 猴 WB, IP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Western blot 1-2 μg/mL, Immunofluorescence: 1-2 μg/mL, Optimal dilution for a specific application should be determined.
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说明
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Positive Control: MCF-7, PC-3, HT29, K562 or Jurkat cell lysates. Human appendix or testis.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Chp2
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别名
- Calcineurin B homologous protein 2
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背景
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Synonyms: Calcineurin B homologous protein 2, Calcineurin-like EF hand protein 2, HCA520, hepatocellular carcinoma antigen gene 520
Gene Symbol: CHP2
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分子量
- 22 kDa
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基因ID
- 63928
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UniProt
- O43745
抗原
-
