CD1a 抗体 (AA 43-173) (CF®647)
Quick Overview for CD1a 抗体 (AA 43-173) (CF®647) (ABIN7650904)
抗原
See all CD1a 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 43-173
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原理
- CD1a / HTA1 (Mature Langerhans Cells Marker)(C1A/3249), CF647 conjugate
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产品特性
- At least five CD1 genes (CD1a, b, c, d, and e) are identified. CD1 proteins have been demonstrated to restrict T cell response to non-peptide lipid and glycolipid antigens and play a role in non-classical antigen presentation. CD1a is a non-polymorphic MHC Class 1 related cell surface glycoprotein, expressed in association with Beta-2 microglobulin. Anti-CD1a labels Langerhans cell histiocytosis (Histiocytosis X), extranodal histiocytic sarcoma, a subset of T-lymphoblastic lymphoma/leukemia, and interdigitating dendritic cell sarcoma of the lymph node. When combined with antibodies against TTF-1 and CD5, anti-CD1a is useful in distinguishing between pulmonary and thymic neoplasms since CD1a is consistently expressed in thymic lymphocytes in both typical and atypical thymomas, but only focally in 1/6 of thymic carcinomas and not in lymphocytes in pulmonary neoplasms. Anti-CD1a is reported to be a new marker for perivascular epithelial cell tumor (PEComa). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant fragment (around aa43-173) of human CD1A protein
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亚型
- IgG2b, kappa
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anti-CD1a (CD1a) antibody
CD1a 适用: 人 IHC, WB, ELISA, ICC 宿主: 小鼠 Monoclonal 7A7 unconjugated
anti-CD1a (CD1a) (AA 151-250) antibodyCD1a 适用: 人 FACS, ELISA, IHC (p), IHC (fro), IF (p), IF (cc) 宿主: 兔 Polyclonal unconjugated
anti-CD1a (CD1a) antibodyCD1a 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal rC1A-711 unconjugated Recombinant Antibody
anti-CD1a (CD1a) antibody (FITC)CD1a 适用: 人 FACS 宿主: 小鼠 Monoclonal HI149 FITC
anti-CD1a (CD1a) antibody (APC)CD1a 适用: 人 FACS 宿主: 小鼠 Monoclonal HI149 APC
anti-CD1a (CD1a) antibody (PE)CD1a 适用: 人 FACS 宿主: 小鼠 Monoclonal HI149 PE
anti-CD1a (CD1a) (AA 1-311) antibodyCD1a 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal M1-2-1B5 unconjugated
anti-CD1a (CD1a) antibodyCD1a 适用: 人, 猕猴 FACS, IF, IHC, WB, StM 宿主: 小鼠 Monoclonal O10 unconjugated
anti-CD1a (CD1a) antibodyCD1a 适用: 人 IHC, StM 宿主: 兔 Monoclonal C1A-1506R unconjugated Recombinant Antibody
anti-CD1a (CD1a) antibodyCD1a 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-001M unconjugated Recombinant Antibody
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应用备注
- For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry
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说明
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Positive Control: MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node or skin.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- CD1a
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别名
- CD1a
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背景
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Synonyms: Cortical thymocyte antigen CD1A, Epidermal dendritic cell marker CD1a, FCB6, HTA1, T cell surface antigen T6 / Leu 6, T-Cell Surface Glycoprotein CD1A
Gene Symbol: CD1A
Tissue Expression: Antigen presenting cells
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分子量
- 49 kDa
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基因ID
- 909
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UniProt
- P06126
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途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
抗原
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