Calcineurin B 抗体 (CF®647)
Quick Overview for Calcineurin B 抗体 (CF®647) (ABIN7650382)
抗原
See all Calcineurin B (CAN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Calcineurin B / PPP3R1(CALNB/2342), CF647 conjugate
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产品特性
- This antibody recognizes the Calcineurin B alpha protein, encoded by the PPP3R1 (Protein Phosphatase 3 Regulatory Subunit B Alpha) gene. Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length Calcineurin B protein
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亚型
- IgG1, kappa
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anti-Calcineurin B (CAN) (AA 1-170) antibody
CAN 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin B (CAN) (AA 1-173) antibodyCAN 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin B (CAN) (AA 1-110) antibodyCAN 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 5D9 unconjugated
anti-Calcineurin B (CAN) (N-Term) antibodyCAN 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin B (CAN) (AA 3-29), (N-Term) antibodyCAN 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB22165 unconjugated
anti-Calcineurin B (CAN) (AA 9-38), (N-Term) antibodyCAN 适用: 人, 小鼠 WB, FACS, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin B (CAN) (AA 1-173) antibodyCAN 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Calcineurin B (CAN) (AA 1-173) antibodyCAN 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.1 mg/mL
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缓冲液
- PBS, 0.1 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Protect from light
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Protect from light
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Calcineurin B (CAN)
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别名
- Calcineurin B
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背景
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Synonyms: Calcineurin B, Calcineurin subunit B type 1, Protein Phosphatase 3 Regulatory Subunit B Alpha, CALNB1, Cna2, CNB, CNB1, PPP3R1
Gene Symbol: PPP3R1
Tissue Expression: Brain|T-cells
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分子量
- 19 kDa
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基因ID
- 5534
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UniProt
- P63098
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途径
- Cellular Glucan Metabolic Process, VEGF Signaling
抗原
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