Calcineurin A 抗体
Quick Overview for Calcineurin A 抗体 (ABIN7650376)
抗原
See all Calcineurin A (CAN) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Calcineurin A / PPP3CA(CALNA/2353)
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产品特性
- This antibody recognizes the Calcineurin A alpha protein, encoded by the PPP3CA (Protein Phosphatase 3 Catalytic Subunit Alpha) gene. Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human Calcineurin A protein
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亚型
- IgG1, kappa
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anti-Calcineurin A (CAN) (AA 15-80) antibody
CAN 适用: 小鼠, 大鼠 WB, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 小鼠 Polyclonal unconjugated
anti-Calcineurin A (CAN) (Center) antibodyCAN 适用: 人 ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin A (CAN) antibodyKD Validated CAN 适用: 人, 小鼠, 大鼠 WB, ICC, FACS, IF 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: HeLa, MCF-7 or A431 cells. Prostate, Thyroid or Pancreas.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- PBS, no BSA, no azide
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储存液
- Without preservative
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储存条件
- -20 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Store at -20 °C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- Calcineurin A (CAN)
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别名
- Calcineurin A
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背景
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Synonyms: Calcineurin A, Calcineurin A alpha, PPP3CA, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform, CALN, CALNA1, CAM-PRP catalytic subunit, CCN1, CNA alpha, CNA1, Protein phosphatase 3 catalytic subunit alpha isoform
Tissue Expression: Brain|T-cells
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分子量
- 62 kDa
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基因ID
- 5530
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UniProt
- Q08209
抗原
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