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Recombinant BCL10 抗体 (AA 122-168)

This anti-BCL10 antibody is a 兔 单克隆 antibody detecting BCL10 in IHC, IF, FACS 和 IHC (fp). Suitable for 人.
产品编号 ABIN7649856
发货至: 中国

Quick Overview for Recombinant BCL10 抗体 (AA 122-168) (ABIN7649856)

抗原

See all BCL10 抗体
BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

抗体类型

Recombinant Antibody

适用

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宿主

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克隆类型

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单克隆

标记

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This BCL10 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

克隆位点

BL10-2988R
  • 抗原表位

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    AA 122-168

    原理

    BCL10 (MALT-Lymphoma Marker) (BL10/2988R)

    产品特性

    B-cell lymphoma/leukemia 10 (BCL10) is a signaling protein that promotes apoptosis, pro-caspase-9 maturation, and activation of NF-kappa-B via NIK and IKK. BCL10 contains an N-terminal caspase recruitment domain (CARD), which is found in a number of apoptotic regulatory molecules. BCL10 is involved in the adaptive immune response, and may be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. A BCL10 translocation is recurrent in low-grade mucosa-associated lymphoid tissue (MALT lymphoma). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    免疫原

    Recombinant human BCL10 protein fragment (around aa122-168)

    亚型

    IgG
  • 应用备注

    Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Immunohistology (formalin): 0.5-1 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

    说明

    Positive Control: HepG2 cells or Lymphoma.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.2 mg/mL

    缓冲液

    PBS, 0.05 % BSA, 0.05 % azide

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    Stable at room temperature or 37°C for 7 days.

    Store at 2 to 8°C. Protect fluorescent conjugates from light

    有效期

    24 months
  • 抗原

    BCL10 (B-Cell CLL/lymphoma 10 (BCL10))

    别名

    BCL10

    背景

    Synonyms: BCL10, BCL-10, B-cell CLL/lymphoma 10, B-cell leukemia/lymphoma 10

    Gene Symbol: BCL10

    分子量

    33 kDa

    基因ID

    8915

    UniProt

    O95999

    途径

    TCR Signaling, Fc-epsilon Receptor Signaling Pathway, Activation of Innate immune Response, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Positive Regulation of Endopeptidase Activity, BCR Signaling, Ubiquitin Proteasome Pathway, S100 Proteins
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