AKR1B1 抗体
Quick Overview for AKR1B1 抗体 (ABIN7649351)
抗原
See all AKR1B1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- Aldo-keto Reductase Family 1 Member B1 (Adrenal Marker)(CPTC-AKR1B1-2)
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产品特性
- Aldo-keto Reductase Family 1 Member B1 (AKR1B1), also known as aldose reductase or aldehyde reductase, is a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This protein catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. It has also been shown to have decreased expression in adrenocortical cancer, and possibly play a role in adrenal tumorigenesis. It has been suggested that AKR1B1 could be investigated as a marker of malignancy for adrenal tumor diagnosis. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
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免疫原
- Recombinant full-length human AKR1B1 protein
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亚型
- IgG1, kappa
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应用备注
- Optimal working dilution should be determined by the investigator.
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说明
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Positive Control: 549, 293T, A431, HeLa, HepG2, MOLT4 and Raji whole cell lysates, HeLa cells, Human colon carcinoma tissue.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.2 mg/mL
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缓冲液
- PBS, 0.05 % BSA, 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
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Stable at room temperature or 37°C for 7 days.
Store at 2 to 8°C. Protect fluorescent conjugates from light
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有效期
- 24 months
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- AKR1B1 (Aldo-Keto Reductase Family 1, Member B1 (Aldose Reductase) (AKR1B1))
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别名
- Aldo-keto Reductase Family 1 Member B1
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背景
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Synonyms: Aldo-keto reductase family 1 member B1, AKR1B1, Aldehyde Reductase 1, Aldose reductase, Lii5-2 CTCL tumor antigen, low Km aldose reductase
Gene Symbol: AKR1B1
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分子量
- 37 kDa
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基因ID
- 231
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UniProt
- P15121
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途径
- Metabolism of Steroid Hormones and Vitamin D, C21-Steroid Hormone Metabolic Process, Monocarboxylic Acid Catabolic Process
抗原
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